2009 | OriginalPaper | Buchkapitel
Optical Imaging of Plastic Changes Induced by Fear Conditioning in the Auditory Cortex of Guinea Pig
verfasst von : Yoshinori Ide, Johan Lauwereyns, Minoru Tsukada
Erschienen in: Advances in Neuro-Information Processing
Verlag: Springer Berlin Heidelberg
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In this study, the plastic change in the auditory cortex induced by fear conditioning with pairing of sound (Conditioned Stimulus, CS) and electric foot-shock (Unconditioned Stimulus, US) was investigated by using of an optical recording. To investigate the effect of associated learning, optical signals in the auditory cortex to CS (12 kHz pure tone) and non-CS (8 kHz and 16 kHz pure tone) were recorded before and after the conditioning. As a result, the response area only to CS increased after the conditioning. On the other hand, to investigate whether auditory information could be retrieved by electric foot-shock after associated learning or not, auditory response to foot-shock alone was also investigated. As a result, the optical response in the auditory cortex to electric foot-shock alone could not be observed before the conditioning but clearly appeared after the conditioning.