Anzeige
Erschienen in:
2015 | OriginalPaper | Buchkapitel
Patient–Specific Parameter Estimation for a Transversely Isotropic Active Strain Model of Left Ventricular Mechanics
verfasst von : Sjur Gjerald, Johan Hake, Simone Pezzuto, Joakim Sundnes, Samuel T. Wall
Erschienen in: Statistical Atlases and Computational Models of the Heart - Imaging and Modelling Challenges
Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.
Wählen Sie Textabschnitte aus um mit Künstlicher Intelligenz passenden Patente zu finden. powered by
Markieren Sie Textabschnitte, um KI-gestützt weitere passende Inhalte zu finden. powered by
Computational models are valuable tools for understanding the mechanical function of the heart. In particular, the prospect of doing patient–specific simulations of heart function may have a significant impact on clinical practice. However, patient–specific simulations give rise to severe challenges related to model choices, parameter fitting and model validation. In this study we investigate parameter variability in a model of left ventricular mechanics applied to four different canine heart cases. The mechanics is modeled by a transversely isotropic active strain model, with two parameters adjusted to fit end diastolic and end systolic pressures and volumes. The chosen model is able to accurately reproduce these data, and enables very efficient parameter fitting. Visual inspection of the resulting deformed geometries also shows a reasonable match with the image based reference.