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Quality of Life Research
Erschienen in: Quality of Life Research 1/2018

08.09.2017

Perceived medication adherence barriers mediating effects between gastrointestinal symptoms and health-related quality of life in pediatric inflammatory bowel disease

verfasst von: James W. Varni, Robert J. Shulman, Mariella M. Self, Shehzad A. Saeed, George M. Zacur, Ashish S. Patel, Samuel Nurko, Deborah A. Neigut, James P. Franciosi, Miguel Saps, Jolanda M. Denham, Chelsea Vaughan Dark, Cristiane B. Bendo, John F. Pohl, On Behalf of the Pediatric Quality of Life Inventory™ Gastrointestinal Symptoms Module Testing Study Consortium

Erschienen in: Quality of Life Research | Ausgabe 1/2018

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Abstract

Objectives

The primary objective was to investigate the mediating effects of patient-perceived medication adherence barriers in the relationship between gastrointestinal symptoms and generic health-related quality of life (HRQOL) in adolescents with inflammatory bowel disease (IBD). The secondary objective explored patient health communication and gastrointestinal worry as additional mediators with medication adherence barriers in a serial multiple mediator model.

Methods

The Pediatric Quality of Life Inventory™ Gastrointestinal Symptoms, Medicines, Communication, Gastrointestinal Worry, and Generic Core Scales were completed in a 9-site study by 172 adolescents with IBD. Gastrointestinal Symptoms Scales measuring stomach pain, constipation, or diarrhea and perceived medication adherence barriers were tested for bivariate and multivariate linear associations with HRQOL. Mediational analyses were conducted to test the hypothesized mediating effects of perceived medication adherence barriers as an intervening variable between gastrointestinal symptoms and HRQOL.

Results

The predictive effects of gastrointestinal symptoms on HRQOL were mediated in part by perceived medication adherence barriers. Patient health communication was a significant additional mediator. In predictive analytics models utilizing multiple regression analyses, demographic variables, gastrointestinal symptoms (stomach pain, constipation, or diarrhea), and perceived medication adherence barriers significantly accounted for 45, 38, and 29 percent of the variance in HRQOL (all Ps < 0.001), respectively, demonstrating large effect sizes.

Conclusions

Perceived medication adherence barriers explain in part the effects of gastrointestinal symptoms on HRQOL in adolescents with IBD. Patient health communication to healthcare providers and significant others further explain the mechanism in the relationship between gastrointestinal symptoms, perceived medication adherence barriers, and HRQOL.
Vorheriger Artikel The roles of physical activity and sedentary behavior on Hispanic children’s mental health: a motor skill perspective
Nächster Artikel Physical activity and health-related quality of life among schoolchildren from disadvantaged neighbourhoods in Port Elizabeth, South Africa

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Literatur
1.
Benchimol, E. I., Fortinsky, K. J., Gozdyra, P., Van den Heuvel, M., Van Limbergen, J., & Griffiths, A. M. (2011). Epidemiology of pediatric inflammatory bowel disease: A systematic review of international trends. Inflammatory Bowel Diseases, 17, 423–439.CrossRefPubMed
2.
Malaty, H. M., Fan, X., Opekun, A. R., Thibodeaux, C., & Ferry, G. D. (2010). Rising incidence of inflammatory bowel disease among children: A 12-year study. Journal of Pediatric Gastroenterology and Nutrition, 50, 27–31.CrossRefPubMed
3.
Varni, J. W., Bendo, C. B., Nurko, S., Shulman, R. J., Self, M. M., Franciosi, J. P., et al. (2015). Health-related quality of life in pediatric patients with functional and organic gastrointestinal diseases. Journal of Pediatrics, 166, 85–90.CrossRefPubMed
4.
Kunz, J. H., Hommel, K. A., & Greenley, R. N. (2010). Health-related quality of life of youth with inflammatory bowel disease: A comparison with published data using the PedsQL 4.0 Generic Core Scales. Inflammatory Bowel Diseases, 16, 939–946.CrossRefPubMedPubMedCentral
5.
Otley, A. R., Griffiths, A. M., Hale, S., Kugathasan, S., Pfefferkorn, M., Mezoff, A., et al. (2006). Health-related quality of life in the first year after a diagnosis of pediatric inflammatory bowel disease. Inflammatory Bowel Diseases, 12, 684–691.CrossRefPubMed
6.
Jackson, C. A., Clatworthy, J., Robinson, A., & Horne, R. (2010). Factors associated with non-adherence to oral medication for inflammatory bowel disease: A systematic review. American Journal of Gastroenterology, 105, 525–539.CrossRefPubMed
7.
Bernstein, C. N. (2015). Treatment of IBD: Where we are and where we are going. American Journal of Gastroenterology, 110, 114–126.CrossRefPubMed
8.
Campos, S., Portela, F., Sousa, P., & Sofia, C. (2016). Inflammatory bowel disease: Adherence to immunomodulators in a biological therapy era. European Journal of Gastroenterology and Hepatology, 28, 1313–1319.CrossRefPubMed
9.
Melesse, D. Y., Targownik, L. E., Singh, H., Blanchard, J. F., & Bernstein, C. N. (2015). Patterns and predictors of long-term nonuse of medical therapy among persons with inflammatory bowel disease. Inflammatory Bowel Diseases, 21, 1615–1622.CrossRefPubMed
10.
Prosberg, M. V., Vester-Andersen, M. K., Andersson, M., Jess, T., Andersen, J. T., Vind, I., et al. (2016). Long-term compliance with oral 5-aminosalicylic acid therapy and risk of disease recurrence in patients with ulcerative colitis: A population-based cohort study. Inflammatory Bowel Diseases, 22, 925–932.CrossRefPubMed
11.
Bhasin, S., Singh, H., Targownik, L. E., Israeli, E., & Bernstein, C. N. (2016). Rates and reasons for nonuse of prescription medication for inflammatory bowel disease in a referral clinic. Inflammatory Bowel Diseases, 22, 919–924.CrossRefPubMed
12.
Spekhorst, L. M., Hummel, T. Z., Benninga, M. A., van Rheenen, P. F., & Kindermann, A. (2016). Adherence to oral maintenance treatment in adolescents with inflammatory bowel disease. Journal of Pediatric Gastroenterology and Nutrition, 62, 264–270.CrossRefPubMed
13.
Hommel, K. A., Davis, C. M., & Baldassano, R. N. (2009). Objective versus subjective assessment of oral medication adherence in pediatric inflammatory bowel disease. Inflammatory Bowel Diseases, 15, 589–593.CrossRefPubMedPubMedCentral
14.
Shi, L., Liu, J., Fonseca, V., Walker, P., Kalsekar, A., & Pawaskar, M. (2010). Correlation between adherence rates measured by MEMS and self-reported questionnaires: A meta-analysis. Health and Quality of Life Outcomes, 8, 99.CrossRefPubMedPubMedCentral
15.
Varni, J. W., Kay, M. T., Limbers, C. A., Franciosi, J. P., & Pohl, J. F. (2012). PedsQL™ Gastrointestinal Symptoms Module item development: Qualitative methods. Journal of Pediatric Gastroenterology and Nutrition, 54, 664–671.CrossRefPubMed
16.
Ingerski, L. M., Baldassano, R. N., Denson, L. A., & Hommel, K. A. (2010). Barriers to oral medication adherence for adolescents with inflammatory bowel disease. Journal of Pediatric Psychology, 35, 683–691.CrossRefPubMed
17.
Gray, W. N., Denson, L. A., Baldassano, R. N., & Hommel, K. A. (2012). Treatment adherence in adolescents with inflammatory bowel disease: The collective impact of barriers to adherence and anxiety/depressive symptoms. Journal of Pediatric Psychology, 37, 282–291.CrossRefPubMed
18.
Chang, L., Toner, B. B., Fukudo, S., Guthrie, E., Locke, G. R., Norton, N. J., et al. (2006). Gender, age, society, culture, and the patient’s perspective in the functional gastrointestinal disorders. Gastroenterology, 130, 1435–1446.CrossRefPubMed
19.
Muris, P., Roelofs, J., Rassin, E., Franken, I., & Mayer, B. (2005). Mediating effects of rumination and worry on the links between neuroticism, anxiety and depression. Personality and Individual Differences, 39, 1105–1111.CrossRef
20.
de Jong-Meyer, R., Beck, B., & Riede, K. (2009). Relationships between rumination, worry, intolerance of uncertainty and metacognitive beliefs. Personality and Individual Differences, 46, 547–551.CrossRef
21.
Barned, C., Stinzi, A., Mack, D., & O’Doherty, K. C. (2016). To tell or not to tell: A qualitative interview study on disclosure decisions among children with inflammatory bowel disease. Social Science and Medicine, 162, 115–123.CrossRefPubMed
22.
Varni, J. W., Shulman, R. J., Self, M. M., Saeed, S. A., Patel, A. S., Nurko, S., et al. (2017). Patient health communication mediating effects between gastrointestinal symptoms and gastrointestinal worry in pediatric inflammatory bowel disease. Inflammatory Bowel Diseases, 23, 704–711.CrossRefPubMed
23.
Varni, J. W., Bendo, C. B., Denham, J., Shulman, R. J., Self, M. M., Neigut, D. A., et al. (2014). PedsQL™ Gastrointestinal Symptoms Module: Feasibility, reliability, and validity. Journal of Pediatric Gastroenterology and Nutrition, 59, 347–355.CrossRefPubMed
24.
Varni, J. W., Bendo, C. B., Denham, J., Shulman, R. J., Self, M. M., Neigut, D. A., et al. (2015). PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in pediatric patients with functional and organic gastrointestinal diseases in comparison to healthy controls. Quality of Life Research, 24, 363–378.CrossRefPubMed
25.
Varni, J. W., Franciosi, J. P., Shulman, R. J., Saeed, S., Nurko, S., Neigut, D. A., et al. (2015). PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in pediatric patients with inflammatory bowel disease in comparison to healthy controls. Inflammatory Bowel Diseases, 21, 1115–1124.CrossRefPubMed
26.
Varni, J. W., Bendo, C. B., Shulman, R. J., Self, M. M., Nurko, S., Franciosi, J. P., et al. (2015). Interpretability of the PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in pediatric patients with functional and organic gastrointestinal diseases. Journal of Pediatric Psychology, 40, 591–601.CrossRefPubMedPubMedCentral
27.
Varni, J. W., Shulman, R. J., Self, M. M., Nurko, S., Saps, M., Saeed, S., et al. (2015). Symptom profiles in patients with irritable bowel syndrome or functional abdominal pain compared to healthy controls. Journal of Pediatric Gastroenterology and Nutrition, 61, 323–329.CrossRefPubMed
28.
Varni, J. W., Nurko, S., Shulman, R. J., Self, M. M., Saps, M., Bendo, C. B., et al. (2015). Pediatric functional constipation gastrointestinal symptom profile compared to healthy controls. Journal of Pediatric Gastroenterology and Nutrition, 61, 424–430.CrossRefPubMed
29.
Varni, J. W., Shulman, R. J., Self, M. M., Saeed, S. A., Patel, A. S., Nurko, S., et al. (2016). Gastrointestinal symptoms predictors of health-related quality of life in patients with inflammatory bowel disease. Journal of Pediatric Gastroenterology and Nutrition, 63, e186–e192.CrossRefPubMed
30.
Varni, J. W., Shulman, R. J., Self, M. M., Nurko, S., Saps, M., Saeed, S. A., et al. (2017). Gastrointestinal symptoms predictors of health-related quality of life in pediatric patients with functional gastrointestinal disorders. Quality of Life Research, 26, 1015–1025.CrossRefPubMed
31.
Varni, J. W., Seid, M., & Kurtin, P. S. (2001). PedsQL™ 4.0: Reliability and validity of the Pediatric Quality of Life Inventory™ Version 4.0 Generic Core Scales in healthy and patient populations. Medical Care, 39, 800–812.CrossRefPubMed
32.
Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Hillsdale, NJ: Erlbaum.
33.
Cohen, J., Cohen, P., West, S. G., & Aiken, L. S. (2003). Applied multiple regression/correlation analysis for the behavioral sciences (3rd ed.). Mahwah, NJ: Erlbaum.
34.
Baron, R. M., & Kenny, D. A. (1986). The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51, 1173–1182.CrossRefPubMed
35.
Preacher, K. J., & Hayes, A. F. (2008). Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behavior Research Methods, 40, 879–891.CrossRefPubMed
36.
Sobel, M. E. (1982). Asymptotic confidence intervals for indirect effects in structural equation models. Sociological Methodology, 13, 290–312.CrossRef
37.
38.
Hayes, A. F. (2013). Introduction to mediation, moderation, and conditional process analysis: A regression-based approach. New York, NY: Guilford.
39.
Jonefjäll, B., Öhman, L., Simrén, M., & Strid, H. (2016). IBS-like symptoms in patients with ulcerative colitis in deep remission are associated with increased levels of serum cytokines and poor psychological well-being. Inflammatory Bowel Diseases, 22, 2630–2640.CrossRefPubMed
40.
Gracie, D. J., Williams, C. J., Sood, R., Mumtaz, S., Bholah, M. H., Hamlin, P. J., et al. (2017). Negative effects on psychological health and quality of life of genuine irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease. Clinical Gastroenterology and Hepatology, 15, 376–384.CrossRefPubMed
41.
Diederen, K., Hoekman, D. R., Hummel, T. Z., de Meij, T. G., Koot, B. G. P., Tabbers, M. M., et al. (2016). The prevalence of irritable bowel syndrome-type symptoms in paediatric inflammatory bowel disease, and the relationship with biochemical markers of disease activity. Alimentary Pharmacology & Therapeutics, 44, 181–188.CrossRef
42.
Greenley, R. N., Gumidyala, A. P., Nguyen, E., Plevinsky, J. M., Poulopoulos, N., Thomason, M. M., et al. (2015). Can you teach a teen new tricks? Problem solving skills training improves oral medication adherence in pediatric patients with inflammatory bowel disease participating in a randomized trial. Inflammatory Bowel Diseases, 21, 2649–2657.CrossRefPubMed
43.
Lönnfors, S., Vermeire, S., Greco, M., Hommes, D., Bell, C., & Avedano, L. (2014). IBD and health-related quality of life: Discovering the true impact. Journal of Crohn’s and Colitis, 8, 1281–1286.CrossRefPubMed
44.
Linn, A. J., van Dijk, L., Smit, E. G., Jansen, J., & van Weert, J. C. (2013). May you never forget what is worth remembering: The relation between recall of medical information and medication adherence in patients with inflammatory bowel disease. Journal of Crohn’s and Colitis, 7, e543–550.CrossRefPubMed
45.
Szigethy, E., Bujoreanu, S. I., Youk, A. O., Weisz, J., Benhayon, D., Fairclough, D., et al. (2014). Randomized efficacy trial of two psychotherapies for depression in youth with inflammatory bowel disease. Journal of the American Academy of Child and Adolescent Psychiatry, 53, 726–735.CrossRefPubMedPubMedCentral
46.
Reigada, L. C., Hoogendoorn, C. J., Walsh, L. C., Lai, J., Szigethy, E., Cohen, B. H., et al. (2015). Anxiety symptoms and disease severity in children and adolescents with Crohn disease. Journal of Pediatric Gastroenterology and Nutrition, 60, 30–35.CrossRefPubMed
47.
Brooks, A. J., Rowse, G., Ryder, A., Peach, E. J., Corfe, B. M., & Lobo, A. J. (2016). Systematic review: Psychological morbidity in young people with inflammatory bowel disease—Risk factors and impacts. Alimentary Pharmacology & Therapeutics, 44, 3–15.CrossRef
48.
Fresco, D. M., Frankel, A. N., Mennin, D. S., Turk, C. L., & Heimberg, R. G. (2002). Distinct and overlapping features of rumination and worry: The relationship of cognitive production to negative affective states. Cognitive Therapy and Research, 26, 179–188.CrossRef
49.
Fialko, L., Bolton, D., & Perrin, S. (2012). Applicability of a cognitive model of worry to children and adolescents. Behaviour Research and Therapy, 50, 341–349.CrossRefPubMed
50.
Keeton, R. L., Mikocka-Walus, A., & Andrews, J. M. (2015). Concerns and worries in people living with inflammatory bowel disease (IBD): A mixed methods study. Journal of Psychosomatic Research, 78, 573–578.CrossRefPubMed
Metadaten
Titel
Perceived medication adherence barriers mediating effects between gastrointestinal symptoms and health-related quality of life in pediatric inflammatory bowel disease
verfasst von
James W. Varni
Robert J. Shulman
Mariella M. Self
Shehzad A. Saeed
George M. Zacur
Ashish S. Patel
Samuel Nurko
Deborah A. Neigut
James P. Franciosi
Miguel Saps
Jolanda M. Denham
Chelsea Vaughan Dark
Cristiane B. Bendo
John F. Pohl
On Behalf of the Pediatric Quality of Life Inventory™ Gastrointestinal Symptoms Module Testing Study Consortium
Publikationsdatum
08.09.2017
Verlag
Springer International Publishing
Erschienen in
Quality of Life Research / Ausgabe 1/2018
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-017-1702-6

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