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Journal of Materials Science

Erschienen in:

02.01.2019 | Materials for life sciences

Phenylboronic acid-functionalized ultra-pH-sensitive micelles for enhanced tumor penetration and inhibition in vitro

verfasst von: Jiejie Qin, Yan Huang, Guoqing Yan, Jun Wang, Liefeng Hu, Panpan Zhang, Rupei Tang

Erschienen in: Journal of Materials Science | Ausgabe 7/2019

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Abstract

In this work, the tumor-targeted ultra-pH-responsive conjugates (PBA/Dex-g-OE) and nontargeted conjugates (Dex-g-OE) were successfully prepared and could easily self-assemble into stable micelles with lower CMC values in neutral aqueous solution. Transmission electron microscopy and dynamic light scattering measurement indicated that the resulting micelles have desirable size distribution and regular spherical shape. The PBA/Dex-g-OE micelles possessed high stability in physiological condition and were pH sensitive to both extracellular and intracellular acidic conditions. Doxorubicin (DOX) was efficiently loaded to give the DOX-loaded micelles (PBA/Dex-g-OE-DOX and Dex-g-OE-DOX) with the desirable drug loading contents. In vitro cellular uptake and growth inhibition assays suggested that PBA/Dex-g-OE-DOX micelles were more efficiently internalized by monolayer tumor cells and three-dimensional multicellular tumor spheroids (MCTS) than nontargeted micelles (Dex-g-OE-DOX), leading to the fast and complete destruction of MCTS in vitro.

Vorheriger Artikel Sedimentation of lithium–iron–phosphate and carbon black particles in opaque suspensions used for lithium-ion-battery electrodes

Nächster Artikel The potential of electrospun poly(methyl methacrylate)/polycaprolactone core–sheath fibers for drug delivery applications

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Titel: Phenylboronic acid-functionalized ultra-pH-sensitive micelles for enhanced tumor penetration and inhibition in vitro
verfasst von: Jiejie Qin
Yan Huang
Guoqing Yan
Jun Wang
Liefeng Hu
Panpan Zhang
Rupei Tang
Publikationsdatum: 02.01.2019
Verlag: Springer US
Erschienen in: Journal of Materials Science / Ausgabe 7/2019
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-018-3092-8

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