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Erschienen in:
Gender Differences in Hospitalization for Acute Myocardial Infarction in Lombardy During the Years 2000–2010 Kapitel lesen Erstes Kapitel lesen

2013 | OriginalPaper | Buchkapitel

PREDESTINATION: PRimary vEntricular fibrillation and suDden dEath during a firST myocardIal iNfArcTION: Genetic Basis

verfasst von : Gaetano M. De Ferrari, Valentina De Regibus, Vincenzo Gionti, Daniela Civardi, Roberto Insolia, Matteo Pedrazzini, Davide Gentilini, Annamaria Di Blasio, Lia Crotti, Peter J. Schwartz

Erschienen in: New Diagnostic, Therapeutic and Organizational Strategies for Acute Coronary Syndromes Patients

Verlag: Springer Milan

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Abstract

Sudden cardiac death (SCD) is the leading cause of death in the age group 20–65 years, in the western world, with an enormous social and economic impact. The majority of the cases of ventricular fibrillation (VF) occur in patients without a preexisting structural heart disease and represent the first manifestation of coronary artery disease. In most of these cases, VF occurs in the early phase of myocardial infarction (MI) and it is then called primary VF. Although several factors have been associated in various studies with primary VF a recent meta-analysis found no evidence for risk factors other than ST elevation and time from onset of symptoms.
In the past several years, few studies have found that a family history of sudden cardiac death (SCD) is a risk factor for primary VF suggesting that this dramatic event may be favored by the genetic background. To explore this possibility we designed the ongoing PREDESTINATION Study, enrolling subjects under 75 years of age with a first MI complicated by primary VF and a control group of subjects with a first uncomplicated MI.
Data so far available confirm the association between a family history of SCD and primary VF and suggest that hypokalemia and prolonged QT interval may favor its occurrence. The genetic analysis has already provided some interesting suggestions that will need to be confirmed by the continuation of the enrolment and joint analysis with data deriving from similar patient populations.

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Vorheriges Kapitel Using Text Mining to Validate Diagnoses of Acute Myocardial Infarction
Nächstes Kapitel MicroRNAs and Tissue Response to Acute Ischemia
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Metadaten
Titel
PREDESTINATION: PRimary vEntricular fibrillation and suDden dEath during a firST myocardIal iNfArcTION: Genetic Basis
verfasst von
Gaetano M. De Ferrari
Valentina De Regibus
Vincenzo Gionti
Daniela Civardi
Roberto Insolia
Matteo Pedrazzini
Davide Gentilini
Annamaria Di Blasio
Lia Crotti
Peter J. Schwartz
Copyright-Jahr
2013
Verlag
Springer Milan
Buch
New Diagnostic, Therapeutic and Organizational Strategies for Acute Coronary Syndromes Patients

Print ISBN: 978-88-470-5378-6

Electronic ISBN: 978-88-470-5379-3

Copyright-Jahr: 2013

DOI
https://doi.org/10.1007/978-88-470-5379-3_6