2015 | OriginalPaper | Buchkapitel
Predicting Standard-Dose PET Image from Low-Dose PET and Multimodal MR Images Using Mapping-Based Sparse Representation
verfasst von : Yan Wang, Pei Zhang, Le An, Guangkai Ma, Jiayin Kang, Xi Wu, Jiliu Zhou, David S. Lalush, Weili Lin, Dinggang Shen
Erschienen in: Machine Learning in Medical Imaging
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Positron emission tomography (PET) has been widely used in clinical diagnosis of diseases or disorders. To reduce the risk of radiation exposure, we propose a mapping-based sparse representation (
m
-SR) framework for prediction of
standard-dose
PET image from its
low-dose
counterpart and corresponding multimodal magnetic resonance (MR) images. Compared with the conventional patch-based SR, our method uses a mapping strategy to ensure that the sparse coefficients estimated from the low-dose PET and multimodal MR images could be directly applied to the prediction of standard-dose PET images. An incremental refinement framework is also proposed to further improve the performance. Finally, a patch selection based dictionary construction method is used to speed up the prediction process. The proposed method has been validated on a real human brain dataset, showing that our method can work much better than the state-of-the-art method both qualitatively and quantitatively.