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2018 | OriginalPaper | Buchkapitel

Preparation and Characterization of Polymer Nanoparticles with Multiple Response

verfasst von : Yushun Jin, Weijin Zhang, Jinhong Zhang, Tianyang He, Lujia Zhang, Yan Shang, Zimo Wang

Erschienen in: Advanced Functional Materials

Verlag: Springer Singapore

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Abstract

Intelligent nanoparticles with core-shell structure have attracted much attention in the field of drug controlled release. 5-fluorouracil (5-FU) is an anti-metabolic drug that inhibits the formation of pyrimidine nucleotides in tumor cells and has a significant effect on a variety of tumors. However, 5-FU is more toxic and has more harmful reactions. In order to reduce the toxicity, the study of its controlled release system is attracting more and more attention. In this paper, PLA macromolecular monomers with double bond functional groups were prepared by ring-opening polymerization of lactide with hydroxyethyl methacrylate as an initiator. And then, N-isopropylacrylamide (NIPAm) was used as the thermosensitive monomer and methacrylic acid (AA) as the pH sensitive monomer, and the PLA macromonomer was subjected to free radical copolymerization. PH reaction, biodegradable properties of amphiphilic copolymer PLA-g-P(NIPAm-co-AA), and 5-fluorouracil are as a kind of model drug preparation of multi-functional nano-anti-tumor drugs. The results of in vitro drug release showed that PLA-g-P(NIPAm-co-AA) nanoparticles released 5-FU slowly in the buffer solution, and the cumulative drug release rate increased slowly with time and showed no bursting, good temperature and pH response. That can more accurately target controlled release drugs, reduce the toxicity of normal tissues and organs, improve its positioning and targeting ability.

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Metadaten
Titel
Preparation and Characterization of Polymer Nanoparticles with Multiple Response
verfasst von
Yushun Jin
Weijin Zhang
Jinhong Zhang
Tianyang He
Lujia Zhang
Yan Shang
Zimo Wang
Copyright-Jahr
2018
Verlag
Springer Singapore
DOI
https://doi.org/10.1007/978-981-13-0110-0_53

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