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2013 | OriginalPaper | Buchkapitel

7. Preparation and Properties of Monodisperse pH-Responsive Microgels

verfasst von : Liang-Yin Chu, Rui Xie, Xiao-Jie Ju, Wei Wang

Erschienen in: Smart Hydrogel Functional Materials

Verlag: Springer Berlin Heidelberg

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Abstract

In this chapter, the design, preparation, and performance of various monodisperse pH-responsive microgels with pH-responsive swelling/shrinking property or pH-responsive stability are introduced. Monodisperse pH-responsive chitosan microspheres and microcapsules with acid-triggered swelling and decomposition properties are developed using uniform-sized water-in-oil (W/O) emulsions as preparation templates via microfluidic approaches. Monodisperse cationic pH-responsive poly(N,N-dimethylaminoethyl methacrylate) (PDM) microgels are successfully prepared by dispersion polymerization in ethanol/water mixture using poly(vinyl pyrrolidone) (PVP) as the steric stabilizer. Monodisperse cationic pH-responsive PDM microcapsules are prepared via UV-initiated polymerization based on a double initiation system. These monodisperse pH-responsive microgels with good biocompatibility are of great potential as smart drug delivery carriers.

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Metadaten
Titel
Preparation and Properties of Monodisperse pH-Responsive Microgels
verfasst von
Liang-Yin Chu
Rui Xie
Xiao-Jie Ju
Wei Wang
Copyright-Jahr
2013
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-642-39538-3_7

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