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Colloid and Polymer Science

Erschienen in:

01.01.2015 | Original Contribution

Preparation of multi-responsive micelles for controlled release of insulin

verfasst von: Guohua Jiang, Tengteng Jiang, Hua Chen, Lei Li, Yongkun Liu, Huijie Zhou, Yu Feng, Jinhua Zhou

Erschienen in: Colloid and Polymer Science | Ausgabe 1/2015

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Abstract

The polymeric micelles were prepared by the copolymerization of poly (methoxypolyethylene glycol acrylamide)-macroinitiator (MePEGA) 3-acrylamide phenylboronic acid (APBA) and 2-nitrobenzyl acrylate (NBA) using a surfactant-free miniemulsion reversible addition fragmentation chain transfer (RAFT) polymerization method. The as-prepared micelles were characterized by ¹H NMR, transmission electron microscopy (TEM), and dynamic light scattering (DLS). Due to the UV light and glucose-sensitivity of as-prepared micelles, the micelles could be used to encapsulate insulin. The insulin release properties of micelles under UV light irradiation and different glucose concentrations were investigated. The micelles exhibited relative lower cytotoxicity and excellent stability against protein solution. The loaded insulin remained the structure stability after release through CD spectra analysis. These results showed that the micelles are one of effective candidate carriers for insulin release.

Vorheriger Artikel Relationship between helical aggregates and polymorphs in a 12-hydroxystearic acid gel: their thermal stability and formation kinetics

Nächster Artikel Adsorption of anionic surfactant sodium dodecyl sulfate onto alpha alumina with small surface area

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Titel: Preparation of multi-responsive micelles for controlled release of insulin
verfasst von: Guohua Jiang
Tengteng Jiang
Hua Chen
Lei Li
Yongkun Liu
Huijie Zhou
Yu Feng
Jinhua Zhou
Publikationsdatum: 01.01.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Colloid and Polymer Science / Ausgabe 1/2015
Print ISSN: 0303-402X
Elektronische ISSN: 1435-1536
DOI: https://doi.org/10.1007/s00396-014-3394-6

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