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Synlett 1999; 1999(2): 193-194
DOI: 10.1055/s-1999-2584
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A Convenient Synthesis of Disubstituted Guanidines via the Mitsunobu Protocol

Hwa-Ok Kim* , Felix Mathew, Cyprian Ogbu
  • *Molecumetics Ltd., 2023 120th Ave. N.E., Bellevue, Washington 98005-2199, USA; Fax +1(4 25)6 46-88 90; E-mail: hkim@molecumetics.com
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Publication History

Publication Date:
31 December 1999 (online)

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An efficient synthetic method for the preparation of disubstituted guanidines is described. Primary and secondary alcohols were treated with guanylating agents under Mitsunobu conditions and their subsequent reactions with amines provided disubstituted guanidines.

disubstituted guanidines - Mitsunobu reaction - monoalkylated guanylating agents

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