1985 | OriginalPaper | Buchkapitel
Prognostic Variables for Survival in a Randomized Comparison of Treatments for Prostatic Cancer
verfasst von : D. F. Andrews, A. M. Herzberg
Erschienen in: Data
Verlag: Springer New York
Enthalten in: Professional Book Archive
Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.
Wählen Sie Textabschnitte aus um mit Künstlicher Intelligenz passenden Patente zu finden. powered by
Markieren Sie Textabschnitte, um KI-gestützt weitere passende Inhalte zu finden. powered by
These data were obtained from a randomized clinical trial comparing four treatments for patients with prostatic cancer in Stages 3 and 4. Stage 3 represents local extension of the disease without evidence of distant metastasis and Stage 4 represents distant metastasis as evidenced by elevated acid phosphatase, x-ray evidence, or both. The trial was double-blinded and the treatments were placebo pill, 0.2 mg diethylstilbestrol, DES, 1.0 mg of DES, or 5.0 mg of DES, all drugs administered daily by mouth. Patients were not required to remain indefinitely on their assigned treatment, but were allowed to have their treatment changed at the discretion of the physician if signs of tumour progression or symptoms appeared. This provision was required for ethical reasons. Patients were followed according to a standard protocol at 6 month intervals or more frequently if required.