2009 | OriginalPaper | Buchkapitel
Protein Structure Prediction by Evolutionary Multi-objective Optimization: Search Space Reduction by Using Rotamers
verfasst von : J. C. Calvo, J. Ortega, M. Anguita, J. M. Urquiza, J. P. Florido
Erschienen in: Bio-Inspired Systems: Computational and Ambient Intelligence
Verlag: Springer Berlin Heidelberg
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The protein structure prediction (PSP) problem is considered an open problem as there is no recognized ”best” procedure to find solutions. Moreover, this problem presents a vast search space and the analysis of each protein conformation requires significant amount of computing time. We propose a reduction of the search space by using the dependent rotamer library. Also this work introduces new heuristics to improve the multi-objective optimization approach to this problem.