In vitro cell systems are well established in the study of mechanisms of neoplastic transformation by a variety of agents including chemicals, ultraviolet light and ionizing radiation (for recent reviews see references 1-4). However, with few exceptions, systems that are used for quantitative studies are rodent-derived cell lines, usually of fibroblastic origin. This situation exists for the very good reason that human cells in culture are extremely difficult to transform, and where this has been achieved the frequency of transformation is three to four orders of magnitude less than that typically seen for rodent cells (2). There is an obvious need for a human cell system(s) for use in in vitro investigations of neoplastic transformation.
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- Radiation-Induced Neoplastic Transformation of Human Cell Hybrids
J. L. Redpath
- Springer US