Projection microstereolithography(PμSL) has some advantages such as precision of several μm, fast fabrication time, and simple fabrication process for complete 3D micro-structure. However, the application of PμSL has limitation due to the liquid material, compared with other additive manufacturing (AM) technology such as fused deposition modeling (FDM) and selective laser sintering (SLS). In this study, we propose the material switching system (MSS) to fabricate a multi-material biomicrostructure in PμSL. The system consists of three control modules; resin level control (RLC), resin dispensing control (RDC), vat level control (VLC). To evaluate the performance of the MSS, the accuracy of resin level has been measured before and after resin exchange. Then, several fabrication methods to reduce the error due to the MSS have been presented. For the application of this system, biodegradable and biocompatible materials have been synthesized and the mechanical and curing properties have been investigated. Several bio-structures of multi-material such as scaffold and transdermal drug delivery system (TDDS) have been fabricated.
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