Several investigators have reported that substance P (SP)-immunoreactive nerve fibers are present in the heart and around coronary blood vessels and intracardiac ganglion cells [1–3]. Experiments with capsaicin have provided strong evidence that SP in the heart and coronary vasculature is in primary sensory nerves [4,5]. These SP-containing afferent nerves could be components of pathways mediating cardiac pain and cardiovascular reflexes. Their anatomical localization also supports the suggestion that SP may be released from peripheral sensory nerve endings and affect coronary blood flow and intracardiac ganglia [2,3]. Thusfar, pharmacological studies have shown that SP is a potent coronary vasodilator .
Weitere Kapitel dieses Buchs durch Wischen aufrufen
- Release of Substance P from Isolated Guinea Pig Heart
D. B. Hoover
- Springer New York
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