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Erschienen in:
The Emperor’s New Body: Seeking for a Blueprint of Limb Regeneration in Humans Kapitel lesen Erstes Kapitel lesen

2011 | OriginalPaper | Buchkapitel

Reponses of Mesenchymal Stem Cells to Varying Oxygen Availability In Vitro and In Vivo

verfasst von : Frank R. Kloss, Sarvpreet Singh, Günter Lepperdinger

Erschienen in: Stem Cell Engineering

Verlag: Springer Berlin Heidelberg

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Abstract

Oxygen is vital for cellular metabolism in higher organisms. Explanted somatic cells are regularly cultured at ambient oxygen conditions, which often appear stressful for primary cells, thereby leading to accelerated aging or premature senescence in vitro. Therefore, sophisticated instrumentation for ex vivo cell manipulation has been introduced and is now increasingly being used for the propagation and subsequent differentiation of various types of stem cells. In this particular context also primary mesenchymal stromal cells (MSC) have been investigated. Their developmental fate greatly depends on oxygen availability.
In this contribution, we describe the current knowledge about MSC properties according to varying oxygen tension in vitro: while reduced oxygen tension supports their proliferation, differentiation potential is reversibly attenuated. This finding is relevant for various in vivo situations such as wound healing or distinct pathologic alterations. Inappropriate oxygenation is actually not impacting on MSC viability, but greatly diminishes their differentiation capabilities, in due course leading to irreversible changes in tissue structure including functional alterations involved.

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Nächstes Kapitel Endothelial Progenitor Cells and Nitric Oxide: Matching Partners in Biomedicine
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Metadaten
Titel
Reponses of Mesenchymal Stem Cells to Varying Oxygen Availability In Vitro and In Vivo
verfasst von
Frank R. Kloss
Sarvpreet Singh
Günter Lepperdinger
Copyright-Jahr
2011
Verlag
Springer Berlin Heidelberg
Buch
Stem Cell Engineering

Print ISBN: 978-3-642-11864-7

Electronic ISBN: 978-3-642-11865-4

Copyright-Jahr: 2011

DOI
https://doi.org/10.1007/978-3-642-11865-4_9

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