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Über dieses Buch

This book summarizes the properties and applications of conventional and commercially available fiber-forming, bioresorbable polymers, as well as those currently under study, for use as biotextiles. Factors affecting the performance of these biomaterials are presented, and precautionary measures to reduce premature, hydrolytic degradation during manufacturing and processing are discussed. Because of the structural requirements of medical devices and the technological advancements in synthetic fibers and textile technology, the new field of "Biotextiles" has evolved to exploit the potential of various woven, knitted, braided and non-woven textile structures for biomedical applications. Textile substrates provide certain unique mechanical properties to the medical device and because of an inherently high level of porosity, they can encourage cell growth and promote migration and proliferation. Bioresorbable devices that assist in the repair and regeneration of damaged tissues have in recent years replaced many of the permanent prosthetic devices. Thus, the topic of “Bioresorbable Biomaterials” generates much interest and research activity in the field of biomaterials science today. For this reason, the use of bioresorbable polymers as fibers is currently dominating the field of resorbable biomaterials for applications from sutures to tissue engineering scaffolds.

Inhaltsverzeichnis

Frontmatter

Chapter 1. Overview of Resorbable Biomaterials

Abstract
Importance of textile based resorbable biomaterials is discussed in this chapter. Requisites for an ideal biomaterial are also given.
Chirag R. Gajjar, Martin W. King

Chapter 2. Degradation Process

Abstract
A resorbable biomaterial degrades either by bulk erosion or by surface erosion mechanisms. The critical device dimension is believed to govern the degradation mechanism. Autocatalytic degradation also plays an important role in the degradation of bulk eroding polymers.
Chirag R. Gajjar, Martin W. King

Chapter 3. Biotextiles: Fiber to Fabric for Medical Applications

Abstract
This chapter describes the importance of fiber-forming biopolymers. Manufacturing processes for biotextiles, and the fabrication of textile structures are also discussed.
Chirag R. Gajjar, Martin W. King

Chapter 4. Hydrolytically Sensitive Fiber-Forming Bioresorbable Polymers

Abstract
There are many different resorbable polymer systems based on different degradation mechanisms, and having a range of physical and mechanical properties. This chapter covers those polymers that are fiber forming and hydrolytically sensitive. Mechanical properties, resorption profile, and medical applications for these polymers have been discussed.
Chirag R. Gajjar, Martin W. King

Chapter 5. Processing Parameters and the Rate of Resorption

Abstract
There are number of factors that affect the rate of resorption of polymers. These factors can be broadly classified under mechanical properties, fabrication process parameters, and in vivo environmental conditions. Though all these factors are important for successful in vivo performance of these polymers, factors such as spinning parameters, processing conditions, sterilization techniques, and packaging are important from the manufacturer's stand point. Effect of these parameters on the resorption rate has been discussed in this chapter.
Chirag R. Gajjar, Martin W. King

Chapter 6. Enzymatically Sensitive Fiber-Forming Bioresorbable Polymers

Abstract
This chapter reviews the fiber-forming resorbable polymers that are sensitive to degradation by enzymes. Mechanical properties, applications, and the mechanism of enzymatic degradation have been discussed.
Chirag R. Gajjar, Martin W. King

Chapter 7. Current Applications of Biotextiles and Future Trends

Abstract
Biotextiles have been used for permanent as well as temporary applications. This chapter reviews the applications of biotextile medical devices along with their structures. Future trends for biotextile devices are also discussed.
Chirag R. Gajjar, Martin W. King

Backmatter

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