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Journal of Materials Science

Erschienen in:

30.08.2017 | Biomaterials

RGD-conjugated titanium dioxide nanoparticles: targeted near-infrared photothermal therapy for α_vβ₃ integrin overexpressed cancer cells

verfasst von: Heng Zhao, Min Wang, Ping Zhou, Quan Wang, Zhiguo Zhou, Danli Wang, Hong Yang, Shiping Yang

Erschienen in: Journal of Materials Science | Ausgabe 23/2017

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Abstract

Photothermal agents, which can convert near-infrared light into heat with a minimal attenuation of the energy and prevent undesirable thermal damage to healthy tissue, provided an opportunity for accurate heat delivery to desired sites. Herein, we designed cyclo(Arg-Gly-Asp-D-Tyr-Lys) peptide c(RGDyK)-conjugated TiO₂ nanoparticles (TiO₂-RGD NPs) with an ideal biocompatibility and targeting property. TiO₂-RGD NPs exhibited intense absorbance in near-infrared region, a high stability in physiological conditions, and the photothermal conversion efficiency of ~38.5%. Due to the specific affinity between c(RGDyK) and α_vβ₃ integrin, TiO₂-RGD NPs showed the high targeting property for U87-MG cells with overexpression of α_vβ₃ integrin. After incubation with TiO₂-RGD NPs (100 µg/mL) and under 808 nm near-infrared laser irradiation (1 W/cm²), the viability of MCF-7 cells by deficient expression of α_vβ₃ integrin was ~71%, while the viability of U87-MG decreased to ~31%, which have been demonstrated as an effective targeting photothermal therapy agent.

Vorheriger Artikel Review of “Biomaterials for Musculoskeletal Regeneration: Concepts, by Bikramjit Basu, Indian Institute of Metals Series, Springer Nature (2016)” and “Biomaterials for Musculoskeletal Regeneration: Applications, by Bikramjit Basu and Sourabh Ghosh, Indian Institute of Metals Series, Springer Nature (2016)”

Nächster Artikel A thin PANI and carrageenan–gold nanoparticle film on a flexible gold electrode as a conductive and low-cost platform for sensing in a physiological environment

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Lin M, Wang D, Liu S, Huang T, Sun B, Cui Y, Zhang D, Sun H, Zhang H, Sun H, Yang B (2015) Cupreous complex-loaded chitosan nanoparticles for photothermal therapy and chemotherapy of oral epithelial carcinoma. ACS Appl Mater Interfaces 7(37):20801–20812. doi:10.1021/acsami.5b05866 CrossRef

Wang S, Tian Y, Tian W, Sun J, Zhao S, Liu Y, Wang C, Tang Y, Ma X, Teng Z, Lu G (2016) Selectively sensitizing malignant cells to photothermal therapy using a CD44-targeting heat shock protein 72 depletion nanosystem. ACS Nano 10(9):8578–8590. doi:10.1021/acsnano.6b03874 CrossRef

Kang S, Bhang SH, Hwang S, Yoon JK, Song J, Jang HK, Kim S, Kim BS (2015) Mesenchymal stem cells aggregate and deliver gold nanoparticles to tumors for photothermal therapy. ACS Nano 9(10):9678–9690. doi:10.1021/acsnano.5b02207 CrossRef

Ke H, Wang J, Dai Z, Jin Y, Qu E, Xing Z, Guo C, Yue X, Liu J (2011) Gold-nanoshelled microcapsules: a theranostic agent for ultrasound contrast imaging and photothermal therapy. Angew Chem 50(13):3017–3021. doi:10.1002/anie.201008286 CrossRef

Liu H, Chen D, Li L, Liu T, Tan L, Wu X, Tang F (2011) Multifunctional gold nanoshells on silica nanorattles: a platform for the combination of photothermal therapy and chemotherapy with low systemic toxicity. Angew Chem 50(4):891–895. doi:10.1002/anie.201002820 CrossRef

Rengan AK, Bukhari AB, Pradhan A, Malhotra R, Banerjee R, Srivastava R, De A (2015) In vivo analysis of biodegradable liposome gold nanoparticles as efficient agents for photothermal therapy of cancer. Nano Lett 15(2):842–848. doi:10.1021/nl5045378 CrossRef

Tsai MF, Chang SH, Cheng FY, Shanmugam V, Cheng YS, Su CH, Yeh CS (2013) Au nanorod design as light-absorber in the first and second biological near-infrared windows for in vivo photothermal therapy. ACS Nano 7(6):5330–5342. doi:10.1021/nn401187c CrossRef

Zhang L, Chen Y, Li Z, Li L, Saint-Cricq P, Li C, Lin J, Wang C, Su Z, Zink JI (2016) Tailored synthesis of octopus-type janus nanoparticles for synergistic actively-targeted and chemo-photothermal therapy. Angew Chem 55(6):2118–2121. doi:10.1002/anie.201510409 CrossRef

Zheng T, Li GG, Zhou F, Wu R, Zhu JJ, Wang H (2016) Gold-nanosponge-based multistimuli-responsive drug vehicles for targeted chemo-photothermal therapy. Adv Mater 28(37):8218–8226. doi:10.1002/adma.201602486 CrossRef

10.

Yao X, Niu X, Ma K, Huang P, Grothe J, Kaskel S, Zhu Y (2016) Graphene quantum dots-capped magnetic mesoporous silica nanoparticles as a multifunctional platform for controlled drug delivery, magnetic hyperthermia, and photothermal therapy. Small. doi:10.1002/smll.201602225

11.

Akhavan O, Ghaderi E (2013) Graphene nanomesh promises extremely efficient in vivo photothermal therapy. Small 9(21):3593–3601. doi:10.1002/smll.201203106 CrossRef

12.

Hs DJ, Kong WH, Sung DK, Lee MY, Beack SE, Keum DH, Kim KS, Yun SH, Hahn SK (2014) Nanographene oxide-hyaluronic acid conjugate for photothermal ablation therapy of skin cancer. ACS Nano 8(1):260–268. doi:10.1021/nn405383a CrossRef

13.

Mou J, Li P, Liu C, Xu H, Song L, Wang J, Zhang K, Chen Y, Shi J, Chen H (2015) Ultrasmall Cu_2-x S nanodots for highly efficient photoacoustic imaging-guided photothermal therapy. Small 11(19):2275–2283. doi:10.1002/smll.201403249 CrossRef

14.

Liu J, Wang P, Zhang X, Wang L, Wang D, Gu Z, Tang J, Guo M, Cao M, Zhou H, Liu Y, Chen C (2016) Rapid degradation and high renal clearance of Cu3BiS3 nanodots for efficient cancer diagnosis and photothermal therapy in Vivo. ACS Nano 10(4):4587–4598. doi:10.1021/acsnano.6b00745 CrossRef

15.

Zhang S, Sun C, Zeng J, Sun Q, Wang G, Wang Y, Wu Y, Dou S, Gao M, Li Z (2016) Ambient aqueous synthesis of ultrasmall PEGylated Cu_2-x Se nanoparticles as a multifunctional theranostic agent for multimodal imaging guided photothermal therapy of cancer. Adv Mater 28(40):8927–8936. doi:10.1002/adma.201602193 CrossRef

16.

Wang J, Zhao H, Zhou Z, Zhou P, Yan Y, Wang M, Yang H, Zhang Y, Yang S (2016) MR/SPECT imaging guided photothermal therapy of tumor-targeting Fe@Fe₃O₄ nanoparticles in vivo with low mononuclear phagocyte uptake. ACS Appl Mater Interfaces 8(31):19872–19882. doi:10.1021/acsami.6b04639 CrossRef

17.

Wang J, Zhou Z, Wang L, Wei J, Yang H, Yang S, Zhao J (2015) CoFe₂O₄@MnFe₂O₄/polypyrrole nanocomposites for in vitro photothermal/magnetothermal combined therapy. RSC Adv 5(10):7349–7355. doi:10.1039/c4ra12733a CrossRef

18.

Guo Z, Zou Y, He H, Rao J, Ji S, Cui X, Ke H, Deng Y, Yang H, Chen C, Zhao Y, Chen H (2016) Bifunctional platinated nanoparticles for photoinduced tumor ablation. Adv Mater. doi:10.1002/adma.201602738

19.

Church GM (2015) Precision chemistry for precision medicine. ACS Cent Sci 1(1):11–13. doi:10.1021/acscentsci.5b00088 CrossRef

20.

Haubner R, Gratias R, Diefenbach B, Goodman SL, Jonczyk A, Kessler H (1996) Structural and functional aspects of RGD-containing cyclic pentapeptides as highly potent and selective integrin α_Vβ₃ antagonists. J Am Chem Soc 118(32):7461–7472. doi:10.1021/ja9603721 CrossRef

21.

Desgrosellier JS, Cheresh DA (2010) Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 10(1):9CrossRef

22.

Cai W, Shin D-W, Chen K, Gheysens O, Cao Q, Wang SX, Gambhir SS, Chen X (2006) Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects. Nano Lett 6(4):669–676. doi:10.1021/nl052405t CrossRef

23.

Danhier F, Breton AL, Préat V (2012) RGD-based strategies to target alpha(v) beta(3) Integrin in cancer therapy and diagnosis. Mol Pharm 9(11):2961CrossRef

24.

Xie J, Chen K, Lee H-Y, Xu C, Hsu AR, Peng S, Chen X, Sun S (2008) Ultrasmall c(RGDyK)-coated Fe₃O₄ nanoparticles and their specific targeting to integrin α_vβ₃-rich tumor cells. J Am Chem Soc 130(24):7542–7543. doi:10.1021/ja802003h CrossRef

25.

Yang H, Qin C, Yu C, Lu Y, Zhang H, Xue F, Wu D, Zhou Z, Yang S (2014) RGD-conjugated nanoscale coordination polymers for targeted T1- and T2-weighted magnetic resonance imaging of tumors in Vivo. Adv Func Mater 24(12):1738–1747. doi:10.1002/adfm.201302433 CrossRef

26.

An L, Hu H, Du J, Wei J, Wang L, Yang H, Wu D, Shi H, Li F, Yang S (2014) Paramagnetic hollow silica nanospheres for in vivo targeted ultrasound and magnetic resonance imaging. Biomaterials 35(20):5381–5392. doi:10.1016/j.biomaterials.2014.03.030 CrossRef

27.

Yang H, Zhuang Y, Sun Y, Dai A, Shi X, Wu D, Li F, Hu H, Yang S (2011) Targeted dual-contrast T₁- and T₂-weighted magnetic resonance imaging of tumors using multifunctional gadolinium-labeled superparamagnetic iron oxide nanoparticles. Biomaterials 32(20):4584–4593. doi:10.1016/j.biomaterials.2011.03.018 CrossRef

28.

Choi J, Song S, Horantner MT, Snaith HJ, Park T (2016) Well-defined nanostructured, single-crystalline TiO₂ electron transport layer for efficient planar perovskite solar cells. ACS Nano 10(6):6029–6036. doi:10.1021/acsnano.6b01575 CrossRef

29.

Zhang J, Jin X, Morales-Guzman PI, Yu X, Liu H, Zhang H, Razzari L, Claverie JP (2016) Engineering the absorption and field enhancement properties of Au-TiO₂ nanohybrids via whispering gallery mode resonances for photocatalytic water splitting. ACS Nano 10(4):4496–4503. doi:10.1021/acsnano.6b00263 CrossRef

30.

Lu X, Chen A, Luo Y, Lu P, Dai Y, Enriquez E, Dowden P, Xu H, Kotula PG, Azad AK, Yarotski DA, Prasankumar RP, Taylor AJ, Thompson JD, Jia Q (2016) Conducting interface in oxide homojunction: understanding of superior properties in black TiO₂. Nano Lett 16(9):5751–5755. doi:10.1021/acs.nanolett.6b02454 CrossRef

31.

Deepagan VG, You DG, Um W, Ko H, Kwon S, Choi KY, Yi GR, Lee JY, Lee DS, Kim K, Kwon IC, Park JH (2016) Long-circulating Au-TiO₂ nanocomposite as a sonosensitizer for ROS-mediated eradication of cancer. Nano Lett. doi:10.1021/acs.nanolett.6b02547

32.

Harada A, Ono M, Yuba E, Kono K (2013) Titanium dioxide nanoparticle-entrapped polyion complex micelles generate singlet oxygen in the cells by ultrasound irradiation for sonodynamic therapy. Biomater Sci 1(1):65–73. doi:10.1039/c2bm00066k CrossRef

33.

Ninomiya K, Ogino C, Oshima S, Sonoke S, Kuroda S, Shimizu N (2012) Targeted sonodynamic therapy using protein-modified TiO₂ nanoparticles. Ultrason Sonochem 19(3):607–614. doi:10.1016/j.ultsonch.2011.09.009 CrossRef

34.

Yamaguchi S, Kobayashi H, Narita T, Kanehira K, Sonezaki S, Kudo N, Kubota Y, Terasaka S, Houkin K (2011) Sonodynamic therapy using water-dispersed TiO₂-polyethylene glycol compound on glioma cells: comparison of cytotoxic mechanism with photodynamic therapy. Ultrason Sonochem 18(5):1197–1204. doi:10.1016/j.ultsonch.2010.12.017 CrossRef

35.

You DG, Deepagan VG, Um W, Jeon S, Son S, Chang H, Yoon HI, Cho YW, Swierczewska M, Lee S, Pomper MG, Kwon IC, Kim K, Park JH (2016) ROS-generating TiO₂ nanoparticles for non-invasive sonodynamic therapy of cancer. Scientific reports 6:23200. doi:10.1038/srep23200 CrossRef

36.

Miyoshi N, Kume K, Tsutumi K, Fukunaga Y, Ito S, Imamura Y, Bibin AB (2011) Application of titanium dioxide (TiO₂) nanoparticles in photodynamic therapy (PDT) of an experimental tumor. AIP Conf Proc 1415(1):21–23. doi:10.1063/1.3667210 CrossRef

37.

Goncalves RH, Schreiner WH, Leite ER (2010) Synthesis of TiO₂ nanocrystals with a high affinity for amine organic compounds. Langmuir ACS J Surf Coll 26(14):11657–11662. doi:10.1021/la1007473 CrossRef

38.

Gordon TR, Cargnello M, Paik T, Mangolini F, Weber RT, Fornasiero P, Murray CB (2012) Nonaqueous synthesis of TiO₂ nanocrystals using TiF₄ to engineer morphology, oxygen vacancy concentration, and photocatalytic activity. J Am Chem Soc 134(15):6751–6761. doi:10.1021/ja300823a CrossRef

39.

Dong A, Ye X, Chen J, Kang Y, Gordon T, Kikkawa JM, Murray CB (2011) A generalized ligand-exchange strategy enabling sequential surface functionalization of colloidal nanocrystals. J Am Chem Soc 133(4):998–1006. doi:10.1021/ja108948z CrossRef

40.

Guo Y, Yuan H, Rice WL, Kumar AT, Goergen CJ, Jokivarsi K, Josephson L (2012) The PEG-fluorochrome shielding approach for targeted probe design. J Am Chem Soc 134(47):19338–19341. doi:10.1021/ja309085b CrossRef

41.

Liu Y, Ai K, Liu J, Deng M, He Y, Lu L (2013) Dopamine-melanin colloidal nanospheres: an efficient near-infrared photothermal therapeutic agent for in vivo cancer therapy. Adv Mater 25(9):1353–1359. doi:10.1002/adma.201204683 CrossRef

Titel: RGD-conjugated titanium dioxide nanoparticles: targeted near-infrared photothermal therapy for αvβ3 integrin overexpressed cancer cells
verfasst von: Heng Zhao
Min Wang
Ping Zhou
Quan Wang
Zhiguo Zhou
Danli Wang
Hong Yang
Shiping Yang
Publikationsdatum: 30.08.2017
Verlag: Springer US
Erschienen in: Journal of Materials Science / Ausgabe 23/2017
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-017-1083-9

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