Serotonin (5-hydroxytryptamine, 5-HT) functions as a neurotransmitter affecting a variety of tissues, including gastrointestinal smooth muscle and striated limb muscle (Bulbring and Gershon, 1967; Ooms et al., 1986). It has also been shown to be a potent vasoconstricting agent (Carter, 1961). As a vasoconstrictor, serotonin causes decreased blood flow through capillaries to skeletal muscles. The decreased oxygen and nutrient exchange between blood and the “isolated” skeletal musculature results in changes in both histological appearance and muscle function (Erspamer, 1961). However, evidence suggesting that serotonin acts more directly on muscle cells has been reported. Attention has been given to studies testing the involvement of receptors responding to 5-HT stimulation in both vascular smooth muscle and skeletal muscle in an effort to discern the receptor subtype which may be in part responsible for the serotonin induced muscle myopathy. Interest has developed in attempting to determine which antagonists for distinct serotonin receptors will be effective therapeutically when administered to animal subjects suffering from serotonin induced myopathies.
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- Serotonin Toxicity Causes Myodeterioration of Skeletal Muscle Function in Albino Mice
Richard L. Mooney
Gerald C. Llewellyn
T. Daniel Kimbrough
- Springer US