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Erschienen in:
2011 | OriginalPaper | Buchkapitel
Simulating the Dynamics of T Cell Subsets throughout the Lifetime
verfasst von : Stephanie J. Foan, Andrew M. Jackson, Ian Spendlove, Uwe Aickelin
Erschienen in: Artificial Immune Systems
Verlag: Springer Berlin Heidelberg
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It is widely accepted that the immune system undergoes age-related changes correlating with increased disease in the elderly. T cell subsets have been implicated. The aim of this work is firstly to implement and validate a simulation of T regulatory cell (T
reg
) dynamics throughout the lifetime, based on a model by Baltcheva. We show that our initial simulation produces an inversion between precursor and mature T
reg
s at around 20 years of age, though the output differs significantly from the original laboratory dataset. Secondly, this report discusses development of the model to incorporate new data from a cross-sectional study of healthy blood donors addressing balance between T
reg
s and T
h
17 cells with novel markers for T
reg
. The potential for simulation to add insight into immune aging is discussed.