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Erschienen in:
Accuracy Assessment of Consensus Sequence from Shotgun Sequencing Kapitel lesen Erstes Kapitel lesen

2011 | OriginalPaper | Buchkapitel

2. Statistical and Computational Studies on Alternative Splicing

verfasst von : Liang Chen

Erschienen in: Handbook of Statistical Bioinformatics

Verlag: Springer Berlin Heidelberg

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Abstract

The accumulating genome sequences and other high-throughput data have shed light on the extent and importance of alternative splicing in functional regulation. Alternative splicing dramatically increases the transcriptome and proteome diversity of higher organisms by producing multiple splice variants from different combinations of exons. It has an important role in many biological processes including nervous system development and programmed cell death. Many human diseases including cancer arise from defects in alternative splicing and its regulation. This chapter reviews statistical and computational methods on genome-wide alternative splicing studies.

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Vorheriges Kapitel Accuracy Assessment of Consensus Sequence from Shotgun Sequencing
Nächstes Kapitel Statistical Learning and Modeling of TF-DNA Binding
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Metadaten
Titel
Statistical and Computational Studies on Alternative Splicing
verfasst von
Liang Chen
Copyright-Jahr
2011
Verlag
Springer Berlin Heidelberg
Buch
Handbook of Statistical Bioinformatics

Print ISBN: 978-3-642-16344-9

Electronic ISBN: 978-3-642-16345-6

Copyright-Jahr: 2011

DOI
https://doi.org/10.1007/978-3-642-16345-6_2