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1987 | OriginalPaper | Buchkapitel

Structure and Post-Translational Processing of the Preprotachykinins

verfasst von : A. J. Harmar, A. R. Pierotti, A. Armstrong, K. Chapman, J. S. Chahl, J. Going, C. R. W. Edwards, R. Rosie, J. Pascall

Erschienen in: Substance P and Neurokinins

Verlag: Springer New York

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Substance P is synthesised from two precursors, α and β preprotachykinin (PPT), which are derived from a single gene by differential RNA splicing [1,2]. We have recently elucidated the cDNA sequence of human β-PPT. The human β-PPT polypeptide contains, in addition to a region encoding SP, the sequences of neurokinin A (NkA) and of neuropeptide K (NpK), an N-terminally extended form of NkA first isolated from porcine brain [3]. We are presently searching for novel fragments of α- and β-PPT which may exhibit biological activity. Rat brain contains a 5,500 Mol. Wt. form of NkA-like immunoreactivity which apparently contains antigenic determinants related to both SP and NkA. This peptide may represent an intermediate in the post-translational processing of β-PPT.

Metadaten
Titel
Structure and Post-Translational Processing of the Preprotachykinins
verfasst von
A. J. Harmar
A. R. Pierotti
A. Armstrong
K. Chapman
J. S. Chahl
J. Going
C. R. W. Edwards
R. Rosie
J. Pascall
Copyright-Jahr
1987
Verlag
Springer New York
DOI
https://doi.org/10.1007/978-1-4612-4672-5_8