1987 | OriginalPaper | Buchkapitel
Substance P and Neurokinins
verfasst von : S. E. Leeman
Erschienen in: Substance P and Neurokinins
Verlag: Springer New York
Enthalten in: Professional Book Archive
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In 1931[1] von Euler and Gaddum reported the presence of a hypotensive substance in extracts of brain and intestine that could stimulate the contraction of various isolated smooth muscles. The active principle in these preparations, a peptide, was later termed substance P. In 1970 [2] Chang and Leeman isolated a sialogogic peptide and soon thereafter characterized it as substance P by multiple biological and chemical criteria.