There is convincing evidence that substance P (SP) is an excitatory neurotransmitter to the muscle of the mammalian gastrointestinal tract . SP also promotes water and electrolyte secretion across the mucosa of the small intestine of the guinea-pig, in vitro, and this effect is largely due to excitation of the secretomotor neurons in the submucosa . Submucous neurons are surrounded by SP immunoreactive varicosities . Many of these neurons are depolarized by SP via a mechanism similar to that responsible for the slow excitatory synaptic potentials that can be evoked in the same neurons by electrical stimulation of the internodal strands [4,5]. These results have led to the suggestion that SP mediates the slow excitatory synaptic potentials .
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- Substance P Binding Sites in Guinea-Pig Enteric Ganglia
J. C. Bornstein
- Springer New York
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