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Polymer Bulletin
Erschienen in: Polymer Bulletin 12/2016

26.04.2016 | Original Paper

Sulfathiazole grafted PEG-PLL as pH-sensitive shielding system for cationic gene delivery

verfasst von: Jialiang Xia, Jie Chen, Lin Lin, Zhaopei Guo, Bing Han, Hongyan Yang, Zongcai Feng, Huayu Tian

Erschienen in: Polymer Bulletin | Ausgabe 12/2016

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Abstract

Polycationic gene carriers, mPEG-b-PLL-g-succinyl sulfathiazole (denoted as PPS), were synthesized and characterized as a shielding system for cationic gene delivery. DNA/PEI/PPS ternary complexes were prepared by shielding PPS to DNA/PEI polyplex solution. PPS can shield the surface charge of DNA/PEI polyplexes from positive (27.7 mV) to negative (−24.6 mV), and the acidic condition should trigger the disassembly of ternary complex. The gene transfection efficiency of DNA/PEI/PPS was lower than DNA/PEI at pH 7.4, but at pH 6.0, it recovered to the same level as DNA/PEI. CLSM results showed the same trend as transfection at different pH. The suitable pH-triggered shielding/deshielding ability estimated that PPS should be a potential shielding system to be used in in vivo gene delivery.
Vorheriger Artikel Polylactic acid and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nano and microparticles for packaging bioplastic composites
Nächster Artikel β-Chitin/gelatin/nanohydroxyapatite composite scaffold prepared through freeze-drying method for tissue engineering applications

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Metadaten
Titel
Sulfathiazole grafted PEG-PLL as pH-sensitive shielding system for cationic gene delivery
verfasst von
Jialiang Xia
Jie Chen
Lin Lin
Zhaopei Guo
Bing Han
Hongyan Yang
Zongcai Feng
Huayu Tian
Publikationsdatum
26.04.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 12/2016
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-016-1688-1

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