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Über dieses Buch

This book focuses on the data mining, systems biology, and bioinformatics computational methods that can be used to summarize biological networks. Specifically, it discusses an array of techniques related to biological network clustering, network summarization, and differential network analysis which enable readers to uncover the functional and topological organization hidden in a large biological network. The authors also examine crucial open research problems in this arena.
Academics, researchers, and advanced-level students will find this book to be a comprehensive and exceptional resource for understanding computational techniques and their applications for a summary of biological networks.

Inhaltsverzeichnis

Frontmatter

Chapter 1. Introduction

Abstract
For decades, scientists have studied the components of living systems in isolation [1].
Sourav S. Bhowmick, Boon-Siew Seah

Chapter 2. Background

Abstract
This chapter provides an overview of key topics that serve as background for the rest of the book. First, we discuss the roles of proteins in living organisms.
Sourav S. Bhowmick, Boon-Siew Seah

Chapter 3. Clustering PPI Networks

Abstract
Due to the availability of large-scale ppi networks, since the last decade significant research efforts have been invested in analyzing these networks in order to comprehend cellular organization and functioning [1].
Sourav S. Bhowmick, Boon-Siew Seah

Chapter 4. Functional Summarization

Abstract
In the preceding chapter, we have discussed an array of techniques for ppi network clustering. In this chapter, we explore recent work in ppi network summarization, a problem that is closely related to clustering.
Sourav S. Bhowmick, Boon-Siew Seah

Chapter 5. Multi-faceted Functional Decomposition

Abstract
In this chapter, we present a ppi decomposition algorithm called facets [1] in order to make sense of the deluge of interaction data using go annotation data.
Sourav S. Bhowmick, Boon-Siew Seah

Chapter 6. Differential Functional Summarization

Abstract
In the preceding chapters, we have focused our discussions on clustering and summarizing static biological networks.
Sourav S. Bhowmick, Boon-Siew Seah

Chapter 7. The Road Ahead

Abstract
In this chapter, we summarize the contributions of this book and establish several lines of inquiry associated with clustering and summarizing biological networks for future research.
Sourav S. Bhowmick, Boon-Siew Seah

Backmatter

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