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Colloid and Polymer Science
Erschienen in: Colloid and Polymer Science 3/2011

01.02.2011 | Original Contribution

Synthesis and multidisciplinary characterization of polyelectrolyte multilayer-coated nanogold with improved stability toward aggregation

verfasst von: Subhra Mandal, Alois Bonifacio, Francesco Zanuttin, Valter Sergo, Silke Krol

Erschienen in: Colloid and Polymer Science | Ausgabe 3/2011

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Abstract

An interesting nanodrug delivery system is polyelectrolyte multilayer-coated nanogold. For better understanding of the binding of polycations or the counter-indicative deposition of polyanions on the citrate-stabilized gold nanoparticles, we used a surface-enhanced Raman spectroscopy to characterize the orientation of the polyions towards the gold surface. It was found that poly-allylamine replaces citrate molecules while the polyanion, poly-styrene sulfonate, intercalates in the citrate shell. One of the major obstacles for polyelectrolyte-coated nanogold is its tendency to agglomerate in the presence of high ion concentration as present, e.g., in blood. A novel encapsulation protocol for polyelectrolyte multilayer coating of gold nanoparticles was developed to successfully overcome this drawback. Moreover, electrostatic functionalization of the polyelectrolyte shell with a model target molecule for cancer, folic acid, induced a significant increase in the particle uptake in folate-receptor over-expressing breast cancer cell lines, VP 229 and MDA MB 231, compared to non-targeted particles or cells (non-activated macrophages) not expressing the folate receptor.
Vorheriger Artikel A three-phase microstructural model to explain the mechanical relaxations of branched polyethylene: a DSC, WAXD and DMTA combined study
Nächster Artikel Isomeric sugar effects on thermal phase transition of aqueous PNIPA solutions, probed by ATR-FTIR spectroscopy; insights to protein protection by sugars

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Metadaten
Titel
Synthesis and multidisciplinary characterization of polyelectrolyte multilayer-coated nanogold with improved stability toward aggregation
verfasst von
Subhra Mandal
Alois Bonifacio
Francesco Zanuttin
Valter Sergo
Silke Krol
Publikationsdatum
01.02.2011
Verlag
Springer-Verlag
Erschienen in
Colloid and Polymer Science / Ausgabe 3/2011
Print ISSN: 0303-402X
Elektronische ISSN: 1435-1536
DOI
https://doi.org/10.1007/s00396-010-2343-2

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