In this presentation synthesized the T
contrast agent, combinations of MRI and optical imaging modalities will be introduced. Using bovine serum albumin conjugated with gadolinium and fluorescence gold or silver nanoclusters (Fluorescence gold /silver protein). An average of 34 Gd-DTPA chelates were covalently conjugated to bovin serum albumin. The T
relaxivity of BSA-Gd-DTPA was 163.27mM
. The experimental results shows a new dual-modal imaging agent of fluorescent gold/silver protein with a paramagnetic in vitro and in vivo, which can be hold many potential applications in medical diagnostics and therapy.