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Polymer Bulletin
Erschienen in: Polymer Bulletin 6/2015

01.06.2015 | Original Paper

Synthesis of poly(vinyl alcohol-graft-lactic acid) copolymer and its application as medical anti-tissue adhesion thin film

verfasst von: Caihua Ni, Ronghui Lu, Lei Tao, Gang Shi, Xuejun Li, Changhu Qin

Erschienen in: Polymer Bulletin | Ausgabe 6/2015

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Abstract

Graft copolymers of poly(vinyl alcohol-g-lactic acid) (PVA-g-PLA) were synthesized through a direct polycondensation of d,l-lactic acid grafting from polyvinyl alcohol (PVA) using 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC·HCl) as the catalyst. The molecular weights of the graft copolymers varied from 98,000 to 106,000, which were determined by gel permeation chromatography. It was observed that the glass transition temperatures of the copolymers decreased with the increase of lactic acid units in the copolymers. Thin films with the thickness of 0.04–0.06 mm were prepared using the copolymers. The films showed improved hydrophilicity and flexibility compared with PLA homopolymer. Small pieces of the films were implanted under the skin of mice for anti-tissue adhesion purpose. The films demonstrated good anti-tissue adhesion behavior and suitable degradability in the mouse body. The graft copolymers were non-toxic, flexible, blood compatible, non-cytotoxic and had potential applications as a medical anti-tissue adhesion agent.
Vorheriger Artikel Preparation and characterization of chitosan–hydroxyapatite–glycopolymer/Cloisite 30 B nanocomposite for biomedical applications
Nächster Artikel Synthesis and characterization of novel maleated poly(d,l-lactide-co-glycolide) by direct melt copolymerization

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Metadaten
Titel
Synthesis of poly(vinyl alcohol-graft-lactic acid) copolymer and its application as medical anti-tissue adhesion thin film
verfasst von
Caihua Ni
Ronghui Lu
Lei Tao
Gang Shi
Xuejun Li
Changhu Qin
Publikationsdatum
01.06.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 6/2015
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-015-1353-0

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