During the last years, huge efforts have been made to upgrade the available tachykinin antagonists. We and several groups have done design studies with purely synthetic permutation series [1,2], others have attempted mathematical predictions based on various physicochemical considerations  but in no case antagonists with pA2-values above 8 were obtained or which satisfied all pharmacological criteria of selectivity and specificity.
Weitere Kapitel dieses Buchs durch Wischen aufrufen
- Tachykinin Antagonists with Cyclic Structures
- Springer New York
Fallstudie Überschwemmungskarten/© Thaut Images | Fotolia