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1987 | OriginalPaper | Buchkapitel

Tachykinins and Gastrointestinal Propulsion in the Rat In Vivo

verfasst von : P. Holzer, U. Holzer-Petsche, S. Leander

Erschienen in: Substance P and Neurokinins

Verlag: Springer New York

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A body of in vitro evidence indicates that substance P (SP) or a related tachykinin is involved in the physiologic regulation of peristalsis in the small intestine of the guinea-pig [1]. However, studies of the effect of SP on gastrointestinal motility in the rat in vivo have not been conclusive [2–4). The first aim of the present study was therefore to systematically investigate the time- and dosedependence of the effect of SP and neurokinin A (NKA) on gastrointestinal propulsion in the rat. The second aim was to provide evidence for a role of endogenous tachykinins in the maintenance of gastrointestinal motility in vivo by examlnlng the effect of a tachykinin antagonist on gastrointestinal propulsion.

Metadaten
Titel
Tachykinins and Gastrointestinal Propulsion in the Rat In Vivo
verfasst von
P. Holzer
U. Holzer-Petsche
S. Leander
Copyright-Jahr
1987
Verlag
Springer New York
DOI
https://doi.org/10.1007/978-1-4612-4672-5_61