A body of in vitro evidence indicates that substance P (SP) or a related tachykinin is involved in the physiologic regulation of peristalsis in the small intestine of the guinea-pig . However, studies of the effect of SP on gastrointestinal motility in the rat in vivo have not been conclusive [2–4). The first aim of the present study was therefore to systematically investigate the time- and dosedependence of the effect of SP and neurokinin A (NKA) on gastrointestinal propulsion in the rat. The second aim was to provide evidence for a role of endogenous tachykinins in the maintenance of gastrointestinal motility in vivo by examlnlng the effect of a tachykinin antagonist on gastrointestinal propulsion.
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- Tachykinins and Gastrointestinal Propulsion in the Rat In Vivo
- Springer New York
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