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07.09.2020 | Original Research

Temperature-responsive hydroxypropyl methylcellulose-N-isopropylacrylamide aerogels for drug delivery systems

verfasst von: Zhongming Liu, Sufeng Zhang, Bin He, Shoujuan Wang, Fangong Kong

Erschienen in: Cellulose | Ausgabe 16/2020

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Abstract

Temperature-responsive aerogels from hydroxypropyl methylcellulose (HPMC)-grafted N-isopropylacrylamide (NIPAM) were developed for the first time as a novel drug delivery system. The morphology and structure of temperature-responsive HPMC-NIPAM aerogels were characterized with scanning electron microscopy, Fourier-transform infrared, X-ray diffraction, and X-ray photoelectron spectroscopic analyses. Water-soluble 5-fluorouracil was used as a model drug to study drug loading and release. Drug release experiments demonstrated a sustained and controlled release behavior of the HPMC-NIPAM aerogels that were highly dependent on temperature. Meanwhile, the first-order kinetic model, Higuchi model, and Korsmyer–Peppas model were used to fit the sustained-release curve of drug-loaded aerogel revealing a sustained-release mechanism.

Vorheriger Artikel Magnetic bacterial cellulose nanofibers for nucleoside recognition

Nächster Artikel Preparation of cellulose-rich membranes from wood: effect of wood pretreatment process on membrane performance

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Titel: Temperature-responsive hydroxypropyl methylcellulose-N-isopropylacrylamide aerogels for drug delivery systems
verfasst von: Zhongming Liu
Sufeng Zhang
Bin He
Shoujuan Wang
Fangong Kong
Publikationsdatum: 07.09.2020
Verlag: Springer Netherlands
Erschienen in: Cellulose / Ausgabe 16/2020
Print ISSN: 0969-0239
Elektronische ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-020-03426-w

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