Antisera to neuropeptides have been used as antagonists of the actions of their respective neuropeptides in the central nervous system [1,2]. If effective, this approach might be particularly useful for determining the roles of neuropeptides for which there are no available antagonists. The present study was prompted by the poor efficacy of substance P (SP) antagonists in the central nervous system. It was considered useful to test SP antiserum in a simple system where the effect of interactions of known concentrations of antiserum and SP may be examined. The aim of this study, therefore, was to determine whether SP antiserum may be used as a chemical antagonist of exogenous and endogenous SP in the guinea-pig isolated ileum.
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- The Effect of Substance P Antiserum on Responses of Guinea-Pig Isolated Ileum to Substance P and Acetylcholine
L. A. Chahl
C. A. Thornton
- Springer New York
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