A single alveolus is used to simulate a breathing cycle in human lungs. An alveolus elastic wall lined with liquid is deformed to accommodate the intrapleural pressure changes. The difference in pressure between alveolus and surroundings is established and the air flow is followed. The main focus, however, is on normal and pathological inhomogeneities which are implemented into the model as decreased tissue elasticity, surfactant deficiency, and constriction of airways. Under such conditions, particle transport and deposition patterns distinguish from those observed in normal healthy lungs.
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- The Influence of Normal and Pathological Inhomogeneities of the Lung Tissues on Particle Transport and Deposition
Dariusz S. Orlicki
- Springer Netherlands
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