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2020 | OriginalPaper | Buchkapitel

The Potential for Nonparametric Joint Latent Class Modeling of Longitudinal and Time-to-Event Data

verfasst von : Ningshan Zhang, Jeffrey S. Simonoff

Erschienen in: Nonparametric Statistics

Verlag: Springer International Publishing

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Abstract

Joint latent class modeling (JLCM) of longitudinal and time-to-event data is a parametric approach of particular interest in clinical studies. JLCM has the flexibility to uncover complex data-dependent latent classes, but it suffers high computational cost, and it does not use time-varying covariates in modeling time-to-event and latent class membership. In this work, we explore in more detail both the strengths and weaknesses of JLCM. We then discuss the sort of nonparametric joint modeling approach that could address some of JLCM’s weaknesses. In particular, a tree-based approach is fast to fit, and can use any type of covariates in modeling both the time-to-event and the latent class membership, thus serving as an alternative method for JLCM with great potential.

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Metadaten
Titel
The Potential for Nonparametric Joint Latent Class Modeling of Longitudinal and Time-to-Event Data
verfasst von
Ningshan Zhang
Jeffrey S. Simonoff
Copyright-Jahr
2020
DOI
https://doi.org/10.1007/978-3-030-57306-5_47