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Erschienen in:
Role of Mesenchymal Stem Cells, Macrophages, and Biomaterials During Myocardial Repair Kapitel lesen Erstes Kapitel lesen

2015 | OriginalPaper | Buchkapitel

2. The Role of Macrophages in the Foreign Body Response to Implanted Biomaterials

verfasst von : Tony Yu, Valerie J. Tutwiler, Dr. Kara Spiller

Erschienen in: Biomaterials in Regenerative Medicine and the Immune System

Verlag: Springer International Publishing

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Abstract

Biomaterials are part of the solution to many unmet clinical needs, from implantable sensors to drug delivery devices and engineered tissues. However, biomaterials face an inflammatory environment upon implantation, representing a potential obstacle to their success. In this chapter, we review the consequences of the foreign body response (FBR) for biomaterial function and strategies that have been used to inhibit the FBR. We focus on the role of the macrophage, the cell at the center of the inflammatory response, and discuss implications of changing macrophage behavior on biomaterial acceptance or rejection. Finally, we discuss recent discoveries in the role of macrophage phenotype, ranging from pro-inflammatory (M1) to anti-inflammatory (M2), and the role it plays in wound healing and biomaterial vascularization. We conclude with a discussion of biomaterial design strategies that have been suggested to positively interact with and potentially control macrophages in order to improve interactions with the inflammatory response.

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Vorheriges Kapitel Role of Mesenchymal Stem Cells, Macrophages, and Biomaterials During Myocardial Repair
Nächstes Kapitel Integrating Tissue Microenvironment with Scaffold Design to Promote Immune-Mediated Regeneration
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Metadaten
Titel
The Role of Macrophages in the Foreign Body Response to Implanted Biomaterials
verfasst von
Tony Yu
Valerie J. Tutwiler
Dr. Kara Spiller
Copyright-Jahr
2015
Buch
Biomaterials in Regenerative Medicine and the Immune System

Print ISBN: 978-3-319-18044-1

Electronic ISBN: 978-3-319-18045-8

Copyright-Jahr: 2015

DOI
https://doi.org/10.1007/978-3-319-18045-8_2

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