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Erschienen in: Journal of Nanoparticle Research 3/2020

01.03.2020 | Research paper

The shape of titanium dioxide nanomaterials modulates their protection efficacy against ultraviolet light in human skin cells

verfasst von: Krunoslav Ilić, Atiđa Selmani, Mirta Milić, Tanja Matijević Glavan, Emilija Zapletal, Marija Ćurlin, Tadahiro Yokosawa, Ivana Vinković Vrček, Ivan Pavičić

Erschienen in: Journal of Nanoparticle Research | Ausgabe 3/2020

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Abstract

Skin protection against ultraviolet (UV) radiation is necessary to reduce sunburn damage (erythema) and has been recognized as an important preventive measure against the development of cancer. Many sun-blocking pharmaceutical products are based on titanium dioxide nanomaterials (TiO2 NMs) due to their UV barrier properties. This study aimed to assess if the UV protective efficiency of TiO2 NMs depends on their shape. We prepared TiO2 nanowires (TNW), TiO2 nanotubes (TNT), and TiO2 nanoplates (TNP) and tested their effects on human keratinocytes before and after UVB irradiation under in vitro exposure settings. The UVB radiation was applied at the dose equivalent to the UV component observed in one medial erythemal dose. The biological effects of TiO2 NMs on nonirradiated and UVB-irradiated keratinocytes were observed by means of cell viability, genotoxicity, and inflammatory response. The obtained results clearly showed that the effects of TiO2 NMs in vitro, either cytotoxic or protective, depend on their shape. These observations highlight the beneficial properties of nanomaterials that can improve the quality and efficacy of nano-enabled products only if the safe-by-design concept has been implemented during the innovation process.

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Metadaten
Titel
The shape of titanium dioxide nanomaterials modulates their protection efficacy against ultraviolet light in human skin cells
verfasst von
Krunoslav Ilić
Atiđa Selmani
Mirta Milić
Tanja Matijević Glavan
Emilija Zapletal
Marija Ćurlin
Tadahiro Yokosawa
Ivana Vinković Vrček
Ivan Pavičić
Publikationsdatum
01.03.2020
Verlag
Springer Netherlands
Erschienen in
Journal of Nanoparticle Research / Ausgabe 3/2020
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI
https://doi.org/10.1007/s11051-020-04791-0

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