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2014 | OriginalPaper | Buchkapitel

5. Tissue Engineering Applications for Peripheral Nerve Repair

verfasst von : Hakan Orbay, Weibo Cai

Erschienen in: Engineering in Translational Medicine

Verlag: Springer London

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Abstract

Peripheral nerve injuries lead to variable levels of functional loss depending on the extent of the injury. Despite the modern treatment methods, peripheral nerve regeneration is still a time-consuming process mainly because of the limited regeneration capacity of the nervous system. Unfortunately, attempts to increase the regeneration potential of the peripheral nervous system yielded a limited improvement. However, Tissue engineering emerged as a more promising tool to ease the traditionally laborious process of peripheral nerve regeneration. A tissue-engineered nerve is a combination of a biodegradable scaffold, a neurogenic cell line, and growth factors. The main focus of current research is to improve the cell–scaffold and scaffold–tissue interactions. Engineering a fully biocompatible and natural nerve-like nerve segment should be possible in the future with the improved understanding of biological mechanisms of nerve healing. This chapter provides a detailed look into the components of tissue-engineered nerve grafts along with a review of clinically relevant studies.

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Vorheriges Kapitel Engineering Biomaterials for Anchorage-Dependent and Non-anchorage-Dependent Therapeutic Cell Delivery in Translational Medicine

Nächstes Kapitel Structure, Function, and Development of Blood Vessels: Lessons for Tissue Engineering

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Titel: Tissue Engineering Applications for Peripheral Nerve Repair
verfasst von: Hakan Orbay
Weibo Cai
Verlag: Springer London
Buch: Engineering in Translational Medicine
Print ISBN: 978-1-4471-4371-0

Electronic ISBN: 978-1-4471-4372-7

Copyright-Jahr: 2014
DOI: https://doi.org/10.1007/978-1-4471-4372-7_5

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