This IMA Volume in Mathematics and its Applications TOPICS IN STOCHASTIC ANALYSIS AND NONPARAMETRIC ESTIMATION contains papers that were presented at the IMA Participating Institution conference on "Asymptotic Analysis in Stochastic Processes, Nonparamet ric Estimation, and Related Problems" held on September 15-17, 2006 at Wayne State University. The conference, which was one of approximately ten selected each year for partial support by the IMA through its affiliates program, was dedicated to Professor Rafail Z. Khasminskii on the occasion th of his 75 birthday, in recognition of his profound contributions to the field of stochastic processes and nonparametric estimation theory. We are grateful to the participants and, especially, to the conference organizers, for making the event so successful. Pao-Liu Chow, Boris Mor dukhovich, and George Yin of the Department of Mathematics at Wayne State University did a superb job organizing this first-rate event and in editing these proceedings. We take this opportunity to thank the Nation al Science Foundation for its support of the IMA.