Patient empowerment frameworks, including personal health records (PHR), actively engage technology empowered citizens in their healthcare. Particularly today, with the current increase of chronic diseases, the high growth rate of the elderly and disabled populations and at the same time the much higher cross-border patient mobility,such systems may prove to be lifesaving, cost effective and time saving. Currently, there are many different online applications promoted as being functional, user-friendly and detailed enough to provide a complete and accurate summary of an individual’s medical history. However, it seems that most of the Web services available do not fully adhere to well known accessibility standards, such as those promoted by the W3C, thus turning them away from people with disability and elderly people, who most probably need them most. Additionally, support for mobile devices introduces additional obstacles to users with disability when trying to operate such services. This paper presents fundamental (
) guidelines for the successful implementation of an accessible ePHR service that can be operated by any patient including people with disabilities irrespective of the device they use to access this service.