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Erschienen in:
A Road Map for Computational Surgery: Challenges and Opportunities Kapitel lesen Erstes Kapitel lesen

2014 | OriginalPaper | Buchkapitel

18. Transport in Nanoconfinement and Within Blood Vessel Wall

verfasst von : A. Ziemys, N. Filipovic, M. Ferrari, M. Kojic

Erschienen in: Computational Surgery and Dual Training

Verlag: Springer New York

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Abstract

The transport of matter is the fundamental biomechanical process in living organisms. It occurs on all time and length scales, from picoseconds to days and from molecular to organ levels. The role of computer modeling is to help elucidating the basic mechanisms in the transport phenomena, investigated experimentally under laboratory and clinical conditions.
In this report we briefly present computational approaches to model transport on small—nanoscale, within nanoconfinement, and on macroscale—considering transport of Low-Density Lipoprotein (LDL) within blood in arterial vessel and within blood vessel tissue. The results illustrate important surface effects on diffusion of molecules when dimensions of diffusion domain are comparable to those of the transporting molecules. On the other hand, the transport model of LDL in the vessel lumen and through tissue and the model of plaque initiation can help in development of drugs and procedures in treating atherosclerosis.

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Vorheriges Kapitel Rule-Based Simulation of Vein Graft Remodeling
Nächstes Kapitel Some Models for the Prediction of Tumor Growth: General Framework and Applications to Metastases in the Lung
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Metadaten
Titel
Transport in Nanoconfinement and Within Blood Vessel Wall
verfasst von
A. Ziemys
N. Filipovic
M. Ferrari
M. Kojic
Copyright-Jahr
2014
Verlag
Springer New York
Buch
Computational Surgery and Dual Training

Print ISBN: 978-1-4614-8647-3

Electronic ISBN: 978-1-4614-8648-0

Copyright-Jahr: 2014

DOI
https://doi.org/10.1007/978-1-4614-8648-0_18

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