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Erschienen in:
2013 | OriginalPaper | Buchkapitel
Understanding Hemodynamics and Its Determinant Factors in Type B Aortic Dissections Using an Equivalent Lumped Model
verfasst von : Paula Rudenick, Bart Bijnens, Constantine Butakoff, David García-Dorado, Arturo Evangelista
Erschienen in: Statistical Atlases and Computational Models of the Heart. Imaging and Modelling Challenges
Verlag: Springer Berlin Heidelberg
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Despite successful initial treatment during the acute phase of aortic dissections, long-term morbidity and mortality of type B aortic dissections is still a clinical challenge. Therefore, the importance of the assessment and understanding of potential variables involved in their long-term outcome, such as flow patterns and pressure profiles in false and true lumen and across tears.
Hence, we developed an equivalent electric 0D model mimicking a type B aortic dissection. The model was calibrated and validated using in-vitro experimental data from a pulsatile flow circuit. We assessed the variation of pressure profiles in the lumina and flow patterns across the tears as a function of changes in tear size and wall compliance.
We found a good concordance between the in-vitro experiments and the predictions from the lumped model.
Therefore, a 0D model of aortic dissection is feasible and offers potential to study pressures and flow pattern alterations in clinical conditions.