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Journal of Materials Science
Erschienen in: Journal of Materials Science 8/2018

16.01.2018 | Biomaterials

Unveiling the slow release behavior of hollow particles with prolonged antibacterial activity

verfasst von: Agni Kumar Biswal, Mohd. Usmani, Shaikh Ziauddin Ahammad, Sampa Saha

Erschienen in: Journal of Materials Science | Ausgabe 8/2018

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Abstract

The aim of this work was to fabricate polylactide-based hollow microspheres to act as slow-release antimicrobial carriers with prolonged antibacterial activity for controlled release applications and also to sharpen our understanding behind its slow release. Hollow particles were fabricated via water/oil/water (w/o/w) double-emulsion method by using hot water to accelerate solvent evaporation rate in order to make hollow core whereas non-hollow (solid) microspheres were formed via simple oil/water (o/w) emulsion method. Interestingly, in vitro release of hydrophilic antibacterial from solid microspheres (hydrophobic) were extremely slow due to strong association between antibacterial and polymer (polylactide) matrix via H-bonding, investigated by Raman microscopy and DSC study. The release rate increases significantly (> 4 times) in the case of hollow particles. The release kinetics study revealed that both hollow and solid particles predominantly followed diffusion-controlled process rather than a degradation pathway. These hollow microspheres demonstrate great promise as antibacterial agents against both gram-negative and gram-positive bacteria over a period of 30 days at 37 °C. The antibacterial effect of these particles was also evaluated on a food model (watermelon juice) and a significant reduction in bacterial growth was observed especially in the case of hollow microparticles. Hence, PLA-based hollow microspheres can be proposed as slow-release antimicrobial carriers for drug delivery or active packaging applications due to its ease of preparation and simplicity.
Vorheriger Artikel Efficient absorption of ibuprofen in aqueous solution using eco-friendly C3N4/soot composite
Nächster Artikel A comparative study on the pore structure of alkali-activated fly ash evaluated by mercury intrusion porosimetry, N2 adsorption and image analysis

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Metadaten
Titel
Unveiling the slow release behavior of hollow particles with prolonged antibacterial activity
verfasst von
Agni Kumar Biswal
Mohd. Usmani
Shaikh Ziauddin Ahammad
Sampa Saha
Publikationsdatum
16.01.2018
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 8/2018
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-018-1991-3

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