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Erschienen in:
1990 | OriginalPaper | Buchkapitel
Use of Mathematics in Assessing Solute Exchange Across the Lung Epithelium
verfasst von : B. T. Peterson, M. L. Collins, J. C. Connelly, J. W. McLarty, D. Holiday, L. D. Gray
Erschienen in: Respiratory Biomechanics
Verlag: Springer New York
Enthalten in: Professional Book Archive
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Our early attempts to understand the role of the lung epithelium in the pathophysiology of lung edema and alveolar flooding were hampered by a lack of techniques for specifically assessing changes in lung epithelial permeability to proteins. Consequently, we have developed two methods for assessing solute exchange across the lung epithelium: 1) the use of nuclear imaging techniques to measure the rate of clearance of aerosolized 99mTc-labeled tracers from the air spaces of the lungs, and 2) the analysis of the clearance of these tracers via the lung lymphatics. Both of these methods employ mathematical modeling techniques to obtain the maximum amount of information from the data.