UVB Prevention of Mouse Skin Tumor Induction by the Initiation-Promotion Protocol

Repeated exposure of mice to UVB (280 to 320 nm) radiation results in the development of a state of tumor-specific suppression that renders the host Incapable of mounting an effective immunological rejection response to antigenic determinants expressed by UV-induced skin tumor cells (1,2). In this system, normal mice can reject transplanted UV-induced tumor cells, whereas UV-treated mice cannot. The objective of this research was to determine if UVB irradiation influences mouse skin tumorigcnesis induced by an initiation-promotion protocol.