Anzeige
Erschienen in:
2015 | OriginalPaper | Buchkapitel
Who Is Talking to Whom: Synaptic Partner Detection in Anisotropic Volumes of Insect Brain
verfasst von : Anna Kreshuk, Jan Funke, Albert Cardona, Fred A. Hamprecht
Erschienen in: Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2015
Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.
Wählen Sie Textabschnitte aus um mit Künstlicher Intelligenz passenden Patente zu finden. powered by
Markieren Sie Textabschnitte, um KI-gestützt weitere passende Inhalte zu finden. powered by
Automated reconstruction of neural connectivity graphs from electron microscopy image stacks is an essential step towards large-scale neural circuit mapping. While significant progress has recently been made in automated segmentation of neurons and detection of synapses, the problem of synaptic partner assignment for polyadic (one-to-many) synapses, prevalent in the
Drosophila
brain, remains unsolved. In this contribution, we propose a method which automatically assigns pre- and postsynaptic roles to neurites adjacent to a synaptic site. The method constructs a probabilistic graphical model over potential synaptic partner pairs which includes factors to account for a high rate of one-to-many connections, as well as the possibility of the same neuron to be pre-synaptic in one synapse and post-synaptic in another. The algorithm has been validated on a publicly available stack of ssTEM images of
Drosophila
neural tissue and has been shown to reconstruct most of the synaptic relations correctly.