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Journal of Polymer Research

Erschienen in:

01.08.2023 | Original Paper

Novel polypeptide composite fibrous scaffold with internal chemical boundary

verfasst von: Shao-Jiun Yang, Tzu-Yi Yu, Jia-Shing Yu, Yu-Ching Huang, Meng-Fang Lin, Wei-Fang Su

Erschienen in: Journal of Polymer Research | Ausgabe 8/2023

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Abstract

Cell migration determines the complete development of mammalian tissue and other pathological phenomena. To investigate the effect of chemical stimuli on such behavior, cells are triggered to translate by the concentration gradient of different molecules on 2D substrates in vitro. But to date unfortunately the polymeric scaffolds for cell migration in 3D environment with chemical stimuli have not been proposed and developed yet. Herein, a novel 3D composite scaffold with an internal chemical boundary is fabricated by electrospinning and mask-assisted electrospray so that the deposition of PBG-N₃ particles is confined at specific area initially. The chemical boundary is subsequently formed after selective surface modification of the particles via click reaction. Using a fluorescent alkyne, the boundary of modified regions is clearly observed by fluorescence microscope. This innovative bio-material has the potential to serve as a promising scaffold for investigating the effect of chemical stimuli on cell migration and growth in 3D environment and further on to the application in tissue engineering.

Vorheriger Artikel Preparation and properties of Na2HPO4·12H2O-expanded pertile shape stable phase change material for building field

Nächster Artikel Highly effective flame retarded TPU introduced by a new phosphorus-containing Schiff base derivative at low addition

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Titel: Novel polypeptide composite fibrous scaffold with internal chemical boundary
verfasst von: Shao-Jiun Yang
Tzu-Yi Yu
Jia-Shing Yu
Yu-Ching Huang
Meng-Fang Lin
Wei-Fang Su
Publikationsdatum: 01.08.2023
Verlag: Springer Netherlands
Erschienen in: Journal of Polymer Research / Ausgabe 8/2023
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI: https://doi.org/10.1007/s10965-023-03695-6

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