Skip to main content
Fachgebiete
Automobil + Motoren Bauwesen + Immobilien Business IT + Informatik Elektrotechnik + Elektronik Energie + Nachhaltigkeit Finance + Banking Management + Führung Marketing + Vertrieb Maschinenbau + Werkstoffe Versicherung + Risiko
DE
EN
Themenseiten
Organisationspsychologie Projektmanagement Marketing Smart Manufacturing
Bücher
Zeitschriften
Weitere Formate
Podcasts Webinare Technik Webinare Wirtschaft Kongresse Veranstaltungskalender Awards
Jetzt Einzelzugang starten
Zugang für Unternehmen
Referenzkunden
ATZ-Fachkongress

Chassis.tech plus 2024


4 Kongresse in einer Veranstaltung

Treffen Sie in München die Fachleute von Chassis, Lenkung, Bremsen sowie Reifen/Räder.
Erweiterte Suche
Anmelden
nach oben
Polymer Science, Series B
Erschienen in: Polymer Science, Series B 6/2022

01.12.2022 | MEDICAL POLYMERS

Synthesis and Characterization of Sterculia Gum Polysaccharide-Poly(bis[2-methacryloyloxy]ethyl Phosphate Copolymeric Network Hydrogels for Use in Drug Delivery

verfasst von: Baljit Singh, Vikrant Sharma, Ankita Kumari

Erschienen in: Polymer Science, Series B | Ausgabe 6/2022

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

The dietary fiber sterculia gum is a therapeutic important polysaccharide comprising of glucuronic–galacturonic acid. In the present work, it has been explored for the development of the crosslinked polymeric network hydrogels with phosphated polymers for use in drug delivery applications. Polymers were characterized by SEM, FTIR, XRD, 13C NMR, TGA-DSC and swelling studies. SEM images of hydrogels showed porous structural heterogeneity. The incorporation of phosphate polymers enhanced the thermal stability of the gum. The swelling of sterculia and phosphate polymers are pH responsive and release of cefuroxime from the polymers occurred slowly with non-Fickian diffusion best fitted in first order kinetic model. The hydrogels showed haemolytic index value < 1 and mucoadhesion with intestinal mucosa = 0.498 ± 0.07 N. These results indicated that these cefuroxime loaded phosphate containing sterculia hydrogels can be explored for the drug delivery applications
Vorheriger Artikel Controlled Synthesis of Copolymers of N-Vinylsuccinamic Acid and Vinyl Alcohol for Immobilization of Low-Molecular-Weight Biologically Active Substances
Nächster Artikel Comparative Analysis of Magnetorheological Effect in Soft Isotropic and Anisotropic Magnetoactive Elastomers

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Jetzt informieren
Literatur
1.
2.
L. Ignat and A. Stanciu, in Handbook of Polymer Blends and Composites, Ed. by A. K. Kulshreshtha and C. Vasile (Rapra Publ. Ltd., Shawbury, 2003), Vol. 3, pp. 275–280.
3.
A. P. Rokhade, S. A. Agnihotri, S. A. Patil, N. N. Mallikarjuna, P. V. Kulkarni, and T. M. Aminabhavi, Carbohydr. Polym. 65, 243 (2006).CrossRef
4.
A. P. Rokhade, S. A. Patil, and T. M. Aminabhavi, Carbohydr. Polym. 67, 605 (2007).CrossRef
5.
6.
7.
B. I. Dahiyat, E. Hostin, E. M. Posadas, and K. W. Leong, J. Biomater. Sci., Polym. Ed. 4, 529 (1993).PubMedCrossRef
8.
9.
10.
H. V. Gangadharappa, M. Rahamath-Ulla, T. M. Pramod-Kumar, and F. Shakeel, Clin. Res. Regul. Aff. 27, 13 (2010).CrossRef
11.
O. S. Reddy, M. C. S. Subha, T. Jithendra, C. Madhavi, and K. C. Rao, Polym. Polym. Compos. 29, 163 (2021).
12.
13.
W. Meer, in Handbook of Water-Soluble Gums and Resins, Ed. by R. L. Davidson, (McGraw-Hill, New York, 1980), pp. 10‒11.
14.
D. Le Cerf, F. Irinei, and G. Muller, Carbohydr. Polym. 13, 375 (1990).CrossRef
15.
16.
B. Singh, “Sterculia Gum: Therapeutic and Biomedical Applications,” in Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, Ed. by M. Mishra (CRC Press, Boca Raton, 2015), pp. 7601–7609.
17.
Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, Ed. by I. A. Khan and E. A. Abourashed, 3rd ed. (John Wiley and Sons, New York, NY, 2009), pp. 393‒395.
18.
G. M. M. Babu, C. D. Prasad, and K. R. Murthy, Int. J. Pharm. 234, 1 (2002).CrossRef
19.
G. V. M. M. Babu, N. R. Kumar, K. H. Sankar, B. J. Ram, N. K. Kumar, and K. V. Murthy, AAPS PharmSciTech 3, 55 (2002).CrossRef
20.
A. Freitas, A. J. Ribeiro, A. C. Santos, F. Veiga, L. C. Nunes, D. A. Silva, and E. C. Silva-Filho, Int. J. Biol. Macromol. 164, 1683 (2020).PubMedCrossRef
21.
22.
23.
F. Rehman, I. U. Khan, S. H. Khalid, S. Asghar, M. Irfan, I. Khalid, N. and U. A. Mohsin, Daru, J. Pharm. Sci. 29, 171 (2021).CrossRef
24.
X. Hu, Y. Wang, L. Zhang, M. Xu, J. Zhang, and W. Dong, Int. J. Biol. Macromol. 108, 558 (2018).PubMedCrossRef
25.
P. B. Krishnappa and V. Badalamoole, Int. J. Biol. Macromol. 122, 997 (2019).CrossRef
26.
C. Vilela, A. P. Martins, N. Sousa, A. J. Silvestre, F. M. Figueiredo, and C. S. Freire, Appl. Sci. 8, 1145 (2018).CrossRef
27.
28.
29.
30.
31.
D. Labarre, Trends Biomater. Artif. Organs 15, 1 (2001).
32.
K. S. C. R. Dos Santos, J. F. J. Coelho, P. Ferreira, I. Pinto, S. G. Lorenzetti, E. I. Ferreira, O. Z. Higa, and M. H. Gil, Int. J. Pharm. 310, 37 (2006).PubMedCrossRef
33.
S. Pinto, P. Alves, C. M. Matos, A. C. Santos, L. R. Rodrigues, J. A. Teixeira, and M. H. Gil, Colloids Surf., B 81, 20 (2010).CrossRef
34.
35.
ASTM F 756-00: Standard Practices for Assessment of Haemolytic Properties of Materials (Am. Soc. Test. Mater., Philadelphia, 2000).
36.
N. Thirawong, J. Nunthanid, S. Puttipipatkhachorn, and P. Sriamornsak, Eur. J. Pharm. Biopharm. 67, 132 (2007).PubMedCrossRef
37.
G. Gorczyca, R. Tylingo, P. Szweda, E. Augustin, M. Sadowska, and S. Milewski, Carbohydr. Polym. 102, 901 (2014).PubMedCrossRef
38.
M. Curcio, F. Puoci, F. Iemma, O. I. Parisi, G. Cirillo, U. G. Spizzirri, and N. Picci, J. Agric. Food Chem. 57, 5933 (2009).PubMedCrossRef
39.
40.
P. B. Krishnappa and V. Badalamoole. Int. J. Biol. Macromol. 122, 997 (2019).CrossRef
41.
P. R. Guru, A. K. Nayak, and R. K Sahu, Colloids Surf., B 104, 268 (2013).CrossRef
42.
43.
C. Vilela, A. P. Martins, N. Sousa, A. J. Silvestre, F. M. Figueiredo, and F. M. Freire, Appl. Sci. 8, 1145 (2018).CrossRef
44.
45.
D. Pooja, S. Panyaram, H. Kulhari, B. Reddy, S. S. Rachamalla, and R. Sistla. Int. J. Biol. Macromol. 80, 48 (2015).PubMedCrossRef
46.
S. C. C. C. Silva, E. M. de Araujo Braz, F. A. de Amorim Carvalho, C. A. R. de Sousa Brito, L. M. Brito, H. M. Barreto, and D. A. da Silva, Int. J. Biol. Macromol. 164, 606 (2020).PubMedCrossRef
47.
48.
M. K. Cheung, K. P. Wan, and P. H. Yu, J. Appl. Polym. Sci. 86, 1253 (2002).CrossRef
49.
A. C. F. Brito, D. A. Silva, R. C. de Paula, and J. P. Feitosa, Polym. Int. 53, 1025 (2004).CrossRef
50.
L. Marvelys, M. Maritza, S. Lilian, L. de Pinto Gladys, and H. Julio, Food Hydrocolloids 20, 908 (2006).CrossRef
51.
A. C. F. Brito, D. A. Silva, R. C. de Paula, and J. P. Feitosa, Polym. Int. 53, 1025 (2004).CrossRef
52.
Y. C. Wang, S. Y. Shen, Q. P. Wu, D. P. Chen, J. Wang, G. Steinhoff, and N. Ma, Macromolecules 39, 8992 (2006).CrossRef
53.
M. T. Nakhjiri, G. B. Marandi, and M. Kurdtabar, J. Polym. Res. 25, 1 (2018).CrossRef
54.
55.
56.
57.
58.
F. Martínez-Gómez, J. Guerrero, B. Matsuhiro, and J. Pavez, Carbohydr. Polym. 155, 182 (2017).PubMedCrossRef
59.
S. Bashir, Y. Y. Teo, S. Ramesh, and K. Ramesh, Polymer 147, 108 (2018).CrossRef
60.
X. Qi, W. Wei, J. Li, Y. Liu, X. Hu, J. Zhang, and W. Dong, ACS Biomater. Sci. Eng. 1, 1287 (2015).PubMedCrossRef
61.
62.
S. L. Tomić, M. M. Mićić, J. M. Filipović, and E. H. Suljovrujić, Radiat. Phys. Chem. 76, 801 (2007).CrossRef
63.
64.
65.
S. Dash, P. N. Murthy, L. Nath, and P. Chowdhury, Acta Pol. Pharm. 67, 217 (2010).PubMed
66.
A. G. Sullad, L. S. Manjeshwar, and T. M. Aminabhavi, Ind. Eng. Chem. Res. 49, 7323 (2010).CrossRef
67.
68.
S. Racovita, M. A. Lungan, I. Bunia, M. Popa, and S. Vasiliu, React. Funct. Polym. 105, 103 (2016).CrossRef
69.
70.
S. Dawlee, A. Sugandhi, B. Balakrishnan, D. Labarre, and A. Jayakrishnan. Biomacromolecules 6, 2040 (2005).PubMedCrossRef
71.
M. Wang, J. Yuan, X. Huang, X. Cai, L. Li, and J. Shen, Colloids Surf., B 103, 52 (2013).CrossRef
72.
73.
74.
75.
76.
77.
S. Hauptstein, S. Bonengel, J. Griessinger, and A. Bernkop-Schnürch, J. Pharm. Sci. 103, 594 (2014).PubMedCrossRef
78.
N. M. N.Le, B. Le-Vinh, J. D. Friedl, A. Jalil, G. Kali, and A. Bernkop-Schnürch, Carbohydr. Polym. 282, 119143 (2022).
79.
T. C. T. Lo, C. A. Chang, K. H. Chiu, P. K. Tsay, and J. F. Jen, Carbohydr. Polym. 86, 320 (2011).CrossRef
80.
81.
82.
J. Liu, Z. Chen, J. Wang, R. Li, T. Li, M. Chang, and Y. Wang, ACS Appl. Mater. Interfaces 10, 16315 (2018).PubMedCrossRef
83.
84.
85.
Metadaten
Titel
Synthesis and Characterization of Sterculia Gum Polysaccharide-Poly(bis[2-methacryloyloxy]ethyl Phosphate Copolymeric Network Hydrogels for Use in Drug Delivery
verfasst von
Baljit Singh
Vikrant Sharma
Ankita Kumari
Publikationsdatum
01.12.2022
Verlag
Pleiades Publishing
Erschienen in
Polymer Science, Series B / Ausgabe 6/2022
Print ISSN: 1560-0904
Elektronische ISSN: 1555-6123
DOI
https://doi.org/10.1134/S1560090422700634

Weitere Artikel der Ausgabe 6/2022

Polymer Science, Series B 6/2022 Zur Ausgabe

FUNCTIONAL POLYMERS

Synthesis and Thermal and Phase Behavior of Polysiloxanes with Grafted Dialkyl-Substituted [1]Benzothieno[3,2-b][1]benzothiophene Groups

FUNCTIONAL POLYMERS

Controlled Copolymerization of Acrylonitrile and Ethyl 2-cyanoacrylate under Reversible Addition-Fragmentation Chain Transfer Conditions and Thermal Behavior of the Obtained Copolymers

COMPOSITES

Comparative Analysis of Magnetorheological Effect in Soft Isotropic and Anisotropic Magnetoactive Elastomers

POLYMER MEMBRANES

Effect of Nanoparticle-Filled Lubricant Layer on Fluoropolymer Slippery Liquid-Infused Porous Surface

DESTRUCTION OF POLYMERS

Investigation of Thermal Properties of Polyureas

FUNCTIONAL POLYMERS

Novel Polyquinolines: Synthesis and Properties

Premium Partner

    Marktübersichten

    Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen. 

    Zur Marktübersicht
    Bildnachweise