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2015 | OriginalPaper | Buchkapitel

The Cellular Chassis as the Basis for New Functionalities: Shortcomings and Requirements

verfasst von : Antoine Danchin

Erschienen in: Synthetic Biology

Verlag: Springer International Publishing

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Abstract

By default synthetic biology refers to construction of synthetic genetic programs. Yet, programs must be expressed within a machine, and the elusive but multipurpose “chassis” is usually taken for granted. The program replicates while the chassis reproduces, showing that maturation, ageing and senescence are core processes which must be taken into account in order to explore realistic outcomes. Functional analysis reveals the essential functions that we need to consider. Some are listed in the present chapter, with emphasis on the role of information recruitment. This is a built-in process of living organisms whose outcome is the production of an ever young progeny as a way to cope with ageing and senescence. Life innovates using Maxwell’s demons-like nanomachines. This is at odds with standard engineering practices, opening up new perspectives for synthetic biology.

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Titel: The Cellular Chassis as the Basis for New Functionalities: Shortcomings and Requirements
verfasst von: Antoine Danchin
Verlag: Springer International Publishing
Buch: Synthetic Biology
Print ISBN: 978-3-319-02782-1

Electronic ISBN: 978-3-319-02783-8

Copyright-Jahr: 2015
DOI: https://doi.org/10.1007/978-3-319-02783-8_8