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Published in:
2020 | OriginalPaper | Chapter
A Guided Network Propagation Approach to Identify Disease Genes that Combines Prior and New Information
Authors : Borislav H. Hristov, Bernard Chazelle, Mona Singh
Published in: Research in Computational Molecular Biology
Publisher: Springer International Publishing
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Abstract
Summary. A major challenge in biomedical data science is to identify the causal genes underlying complex genetic diseases. Despite the massive influx of genome sequencing data, identifying disease-relevant genes remains difficult as individuals with the same disease may share very few, if any, genetic variants.